[HTML][HTML] Diet-Induced Hypercholesterolemia Leads to Cardiac Dysfunction and Alterations in the Myocardial Proteome

MR Szabó, M Pipicz, M Sárközy, B Bruszel… - International Journal of …, 2022 - mdpi.com
… Subsequently, bioinformatic analyses (pathway enrichment … indicating
hypercholesterolemia-induced rearrangements of … stress and enhanced proinflammatory cytokine

[HTML][HTML] Posible mecanismo molecular de la cápsula Xiexin en la intervención de la dislipidemia basada en la bioinformática y el acoplamiento molecular

K Yao, H Cai, Y Wang, S Cheng, Q Liu… - Nutrición …, 2022 - SciELO Espana
Bioinformatics is the result of integrating medicine, computer … Therefore, bioinformatics can
further effectively guide the … Based on this, this paper uses bioinformatic methods to study the …

Hypercholesterolemia impairs clearance of neutrophil extracellular traps and promotes inflammation and atherosclerotic plaque progression

UK Dhawan, P Bhattacharya, S Narayanan… - … , and vascular biology, 2021 - Am Heart Assoc
… level of DNase in attenuating disease pathogenesis. However, … whether the
hypercholesterolemia-induced decrease in … for quantification of proinflammatory cytokine levels in …

MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia

H Chen, J Gao, Q Xu, D Wan, W Zhai… - Canadian Journal of …, 2021 - cdnsciencepub.com
… of chronic metabolic diseases like hypercholesterolemia, diabetes mellitus, and obesity, which
… With the assistance of bioinformatics analysis, we confirmed that PAK7 served as a target …

[HTML][HTML] The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment

L Ramos-Regalado, S Alcover, L Badimon, G Vilahur - Cells, 2024 - mdpi.com
… A comprehensive bioinformatics analysis has reported ten … mice, whereas this correlation
was attenuated or even absent in the … the ischemic diabetic heart, controlling the inflammatory

[HTML][HTML] Molecular targets and mechanisms of Guanxinning tablet in treating atherosclerosis: Network pharmacology and molecular docking analysis

C Niu, P Zhang, L Zhang, D Lin, H Lai, D Xiao, Y Liu… - Medicine, 2023 - journals.lww.com
… and analysis platform and bioinformatics analysis tool for … decrease inflammation and
oxidative stress to attenuate AS. [ … significantly increased in type 2 diabetes mellitus patients. [ …

[HTML][HTML] iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia

IS Zakharova, AI Shevchenko, MA Arssan… - International Journal of …, 2024 - mdpi.com
… is considered to be pathogenic according to bioinformatic predictions, as it interferes with …
of proinflammatory cytokines and preventing the expression of inflammatory receptors [56]. …

[HTML][HTML] Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia

S Sukhanov, Y Higashi, T Yoshida, S Danchuk… - JCI insight, 2023 - ncbi.nlm.nih.gov
… Oxidative stress is a major characteristic of hypercholesterolemia-induced atherosclerosis (…
FH pigs, which may have contributed to attenuation of atherosclerosis progression, leading to …

Torularhodin-loaded bilosomes ameliorate lipid accumulation and amino acid metabolism in hypercholesterolemic mice

C Liu, Y Guo, Y Cheng, H Qian - Journal of Agricultural and Food …, 2023 - ACS Publications
… Finally, interaction network bioinformatics was used to … mortality worldwide, and
hypercholesterolemia induced by a high… an HFHCD expressed more inflammatory cytokines in the …

In vitro Study of Antiatherogenic Effect of Punicalagin on the Regulation of Gene Expression in Macrophage Cells

SJ Almowallad - 2021 - platform.almanhal.com
… (CVD), is an unending inflammatory response process in which the coronary arteries, cerebral
arteries, and aorta get lesions and produce pro-inflammatory cytokines. Atherosclerosis is …