Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2‐arachidonoyl‐glycerol and its congeners in human …

C Turcotte, AS Archambault, E Dumais… - The FASEB …, 2020 - Wiley Online Library
… To better mimic their fate, adenosine deaminase (0.3 U/mL) was added 10 minutes … AA-induced
2-AG biosynthesis and the EPA-induced 2-EPG biosynthesis is likely the consequence …

[HTML][HTML] New insights into peptide cannabinoids: structure, biosynthesis and signaling

A Riquelme-Sandoval, CO de Sá-Ferreira… - Frontiers in …, 2020 - frontiersin.org
… evidence on lipid endocannabinoids, cannabinoid receptors … the pharmacological effects,
the biosynthesis of the peptide … metabolism, cell survival, cell fate and apoptosis. They activate …

[HTML][HTML] The biochemistry of phytocannabinoids and metabolic engineering of their production in heterologous systems

K Blatt-Janmaat, Y Qu - International Journal of Molecular Sciences, 2021 - mdpi.com
… The discovery of the biosynthesis of major … This review summarizes the biosynthesis of major
phytocannabinoids … to the discovery of the endocannabinoid ligands such as anandamide …

Mechanisms of endocannabinoid control of synaptic plasticity

BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
… Over the past 30 years it has been shown that this endocannabinoid system acts widely
throughout the nervous system. This has shed light on the role of the endogenous cannabinoid …

[HTML][HTML] Biosynthesis of phytocannabinoids and structural insights: a review

RK Govindarajan, AK Mishra, KH Cho, KH Kim… - Metabolites, 2023 - mdpi.com
… The endocannabinoid system also plays a key role in neural and molecular control … once
additional biosynthetic pathways have been elucidated [104,105]. The fate and durability of non-…

Biosynthetic origins of unusual cannabimimetic phytocannabinoids in Cannabis sativa L: a review

MT Welling, MA Deseo, A Bacic, MS Doblin - Phytochemistry, 2022 - Elsevier
… the human endocannabinoid system (ECS). While understanding of the biosynthesis of the
… ) has grown rapidly in recent years, the biosynthetic origin and genetic regulation of many …

[HTML][HTML] The epigenetics of the endocannabinoid system

R Meccariello, A Santoro, S D'Angelo… - International journal of …, 2020 - mdpi.com
… Apart from endocannabinoid biosynthesis, which is mediated … feature of endocannabinoid
signalling is the modulation of … Once established at embryo stage to define cell fate through the …

The Function of the Endocannabinoid System

ND Winters, S Patel - Marijuana and Madness, 2023 - books.google.com
… THC exerts its psychoactive effects through activation of type-1 cannabinoid (CB1) receptors,
which are a major component of the endogenous cannabinoid (endocannabinoid; eCB) …

Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and …

C Turcotte, É Dumais, AS Archambault… - Journal of leukocyte …, 2019 - academic.oup.com
… or the use of endocannabinoid hydrolysis inhibitors in order … , in part, by eicosanoid
biosynthetic enzymes to form LTB 4 … determining the fate of G-containing endocannabinoids in an …

On the biomedical properties of endocannabinoid degradation and reuptake inhibitors: Pre-clinical and clinical evidence

KJ Paredes-Ruiz, K Chavira-Ramos… - Neurotoxicity …, 2021 - Springer
endocannabinoid system (ECS) is composed of endogenous cannabinoids (endocannabinoids
), and the enzymes responsible for the biosynthesis and metabolism of their endogenous …