… upon treatment with diphenyl azidophosphate (DPPA). … novel modulators of VEGFR-2
signaling, the pharmacorphore-combination strategy was introduced by incorporating diaryl urea …

… urea) derivatives and their inhibitory activity against VEGFR-2 revealed that substituted
phenyl urea derivatives … than the phenyl urea derivative 7a as VEGFR-2 inhibitors. Moreover, …

… urea derivatives at position-4 and vinyl moiety at position-2 to successfully deliver a novel
series of potent antitumor agents as VEGFR-2 … the O linker and the biphenyl urea moieties. The …

… Discovery of VEGFR-2 inhibitors capable of intervening with … Structurally diverse VEGFR-2
inhibitors (ATP analogs) with … core, and sorafenib 3 with a urea segment [7] (Fig. 1). …

… -1,3,4-thiadiazole-aryl urea derivatives 11a-m to evaluate their … vessels, and inhibition of
VEGFR-2 phosphorylation were … of novel drugs to treat tumors, particularly prostate cancer. …

… on the development of novel VEGFR-2 inhibitors. Many … a and 34 c ) instead of urea moiety
increased enzymatic activity and … 1 N–H of the urea unit of sorafenib formed a hydrogen bond …

… of VEGFR-2 inhibitors, 17 novel compounds were designed … and donors in some VEGFR-2
inhibitor drugs as Regorafenib … So that urea and amide moieties were designed in this work …

… derivatives with potential VEGFR-2 kinase inhibition and anticancer activities, we synthesized
… In summary, we designed and synthesized a novel class of 6-amide-2-aryl benzoxazole …

… co-workers reported the synthesis of novel benzylidene urea derivatives upon reaction of o-…
of VEGFR-2 inhibitors containing a biphenyl urea and an oxime moiety. Urea derivative 115 …

… activated cyanoacrylic acid unit as a potential reversible inhibitor of … VEGFR-2’s major role
is proangiogenic signaling. The … , we sought to synthesize novel fused indazole-diphenyl urea…