… VEGFR-2 kinase inhibitors from docking study, these … group at urea moiety formed two H-bonds
with Glu883 at a distance of 1.81 … Design, synthesis and in vitro antitumor activity of novel …

… be a potent VEGFR-2/HDAC inhibitor. Therefore validating the … [146] synthesized a novel
class of 2,3-diphenyl acrylic acid … as a capping and spacer unit of HDAC inhibitors with an IC50 …

… with activity being achieved via induction of novel linking … synthesized a series of 4-anilinoquinazoline-diaryl
urea hybrids and evaluated their ability to inhibit EGFR and VEGFR-2…

… In this survey, we present novel derivatives of DHPM-calix[4]… to discover novel EGFR
mutant inhibitors. some series of new … Then, diphenyl ether is added and to remove the water, …

… and tert-butyl urea confer potent enzymatic affinity and … 4) through virtual screening of
VEGFR-2 inhibitors targeting … zole derivatives as novel small-molecule inhibitors of VEGFR-2. …

… Numerous drugs inhibited VEGFR-2 rather than EGFR kinases and had superior … VEGF/VEGFR-2
signaling pathway responsiveness can help in the design of novel drugs. …

… The VEGFR-2 receptor is involved in angiogenesis via par… signalling pathway to the VEGFR-2
receptor could be potential … -3-yl derivatives as VEGFR-2 inhibitors. These compounds …

… approach was employed to synthesize a novel series of coumarin … 14) by anodic oxidation
of 1,5diphenyl -dihydropyrazole in … endothelial growth factor-2 (VEGFR-2) and p38 MAPK. In …

… the synthesis of the aminopyrimidine nucleus are of great interest. This comprehensive review
focuses the different approaches based on novel … nucleophilic addition of urea to activated …

… 2.2 nM and strong inhibitory effect against VEGFR-2 at 74 nM [49]… biphenyl-aryl urea and
salicylaldoxime [71]. These two … a series of novel boron-incorporated derivatives of evodiamine …