[HTML][HTML] Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis
C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
… have shown that blocking sepsis-induced DC apoptosis or … apoptosis could be a new
therapeutic approach in sepsis. Further, exploring potential therapeutic targets related to apoptosis …
therapeutic approach in sepsis. Further, exploring potential therapeutic targets related to apoptosis …
[HTML][HTML] The pathogenesis of sepsis and potential therapeutic targets
M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
… organs during sepsis, and an inhibition of apoptosis by using … identification of infections,
rational employment of antibiotics, … -1/PD-L1 blockade can be used to treat sepsis. To investigate …
rational employment of antibiotics, … -1/PD-L1 blockade can be used to treat sepsis. To investigate …
[HTML][HTML] New agents in development for sepsis: any reason for hope?
P Vignon, PF Laterre, T Daix, B François - Drugs, 2020 - Springer
… to consider that a single therapeutic strategy or medication would provide … , blocking
PD-1/PD-L1 pathway with anti-PD-1 or anti-PD-L1 antibodies in septic patients decreased apoptosis …
PD-1/PD-L1 pathway with anti-PD-1 or anti-PD-L1 antibodies in septic patients decreased apoptosis …
[HTML][HTML] MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets
W Zhang, X Fang, C Gao, C Song, Y He, T Zhou… - Cytokine & Growth …, 2023 - Elsevier
… sepsis patients by suppressing monocytes, neutrophils and effector T cells [5]. Therefore, the
reversal of lymphocyte apoptosis is a challenging aspect of sepsis treatment. … and blockade …
reversal of lymphocyte apoptosis is a challenging aspect of sepsis treatment. … and blockade …
The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective
… to the induction of abnormal apoptosis in different organs, … therapeutic strategies may be
employed to treat sepsis, or at … growth of sepsis-induced bacteria, (2) blocking the binding of …
employed to treat sepsis, or at … growth of sepsis-induced bacteria, (2) blocking the binding of …
[HTML][HTML] Immune checkpoints: novel therapeutic targets to attenuate sepsis-induced immunosuppression
MA McBride, TK Patil, JK Bohannon… - Frontiers in …, 2021 - frontiersin.org
… with anti-CTLA4 antibody attenuates T cell apoptosis and improves survival in CLP induced
sepsis (… therapeutic approach using immune checkpoint blockade in conjunction with other …
sepsis (… therapeutic approach using immune checkpoint blockade in conjunction with other …
[HTML][HTML] Melatonin for the treatment of sepsis: the scientific rationale
RMLC Biancatelli, M Berrill… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
… ER mediated cell apoptosis, was reestablished by melatonin, probably through the MAPK/ERK
pathway (66). Lastly, melatonin protects mitochondria by blocking the overexpression of …
pathway (66). Lastly, melatonin protects mitochondria by blocking the overexpression of …
[HTML][HTML] Nanomedicine for acute respiratory distress syndrome: the latest application, targeting strategy, and rational design
Q Qiao, X Liu, T Yang, K Cui, L Kong, C Yang… - … Pharmaceutica Sinica B, 2021 - Elsevier
… , causing apoptosis/necrosis of … infection often causes lesions that are located in lower
lobes instead of upper lobes, and progresses more rapidly compared with SARS-CoV infection…
lobes instead of upper lobes, and progresses more rapidly compared with SARS-CoV infection…
[HTML][HTML] Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms
… search on therapeutic strategies aiming at treating sepsis or … Several authors have described
the effect of C5a blockade in … ), anti-C5a treatment lowered thymocyte apoptosis by 80%. …
the effect of C5a blockade in … ), anti-C5a treatment lowered thymocyte apoptosis by 80%. …
[HTML][HTML] Nanoplatforms for sepsis management: rapid detection/warning, pathogen elimination and restoring immune homeostasis
G Luo, J Zhang, Y Sun, Y Wang, H Wang, B Cheng… - Nano-micro letters, 2021 - Springer
… the rationality of nanoplatforms in sepsis management is … sepsis and future therapeutic
concepts, summarizing the progress of these well-designed nanoplatforms in sepsis management …
concepts, summarizing the progress of these well-designed nanoplatforms in sepsis management …