… in situ (brain perfusion) blood–brain barrier models are also presented. The drug formulations
and … With these techniques more effective and even safer drugs can be developed for the …

… and adaptable barrier) affects approaches of CNS drug delivery … effective drugs is hindered
by numerous drawbacks intrinsic to … Because of its physiological relevance, the permeability …

… of effective therapies to the central nervous system (CNS). … will improve physiological relevance
and disease modeling for … be inhibited to increase drug efficacy to the CNS [72]. Despite …

… reach homogeneous and effective drug concentrations within … Due to challenges in developing
small CNS drugs that better … proven efficacious in animal models of GBM with prolonged …

… blood–brain barrier (BBB). Thus, despite the large number of potential drug candidates, the
choice of effective … out that the glioma model employed can affect in a relevant manner the …

… their interaction with the BBB and CNS, medicine needs to reduce its reliance on costly and
arduous in vivo models… , and are of great importance for CNS drug delivery. A nanocarrier …

… The design of a drug that successfully overcomes the … Therefore, this review focuses on
describing the importance of … CNS-related disorders when speaking of delivering drugs to the …

… many models of the brain barriers have been developed to study … in CNS drug delivery
(Table 1), and their localization in the … These models have been of great importance for the …

… of drugs to treat central nervous system (CNS) disorders. … the successful development of
RMT/CMT-based brain delivery … of therapeutically relevant drug doses into the CNS with minimal …

… results of successful delivery of drugs to the brain via receptor-… -based successful drug
delivery to the CNS and their … shown the importance as CT contrast agent in a rat model after …