… isolated from bone marrow, were proposed to be used for the treatment of age-related
diseases (heart … Additionally, the study of bone marrow MSC aging is important in the context of …

… For example, with advancing age, the activity of hematopoietic stem cells decreases, which
can lead to a series of pathological manifestations, such as a reduced adaptive immune …

… stem cells to prevent age-related disorders still remains unknown. Here, we show that chronic
application of human embryonic stem cell-… prevents age-related bone loss in ageing mice. …

… Genome wide studies have identified multiple age related genes regulated during aging,
such as lysine specific demethylases (kdm3a-b, kdm5-d and kdm6a-b) with established roles in …

… stem cells under a quiescent state [29]. Currently, it is generally accepted that the stem cell
niche includes the supporting cells… Under normal conditions, the niche maintains stem cells in …

… Expression levels of age-related and autophagy-related … MSCs were successfully implanted
into the bone marrow of aging … , aging is currently considered to be a gene-related disease. …

… in the context of aging and age-related diseases. Here, we … of EVs derived from mesenchymal
stem cells (MSC-EVs). … -aging signals and rejuvenate senescing adult bone marrow–…

… W, effectively cleared SCs, senescent bone marrow hematopoietic stem cells (HSCs), and
senescent muscle stem cells (MuSCs) from either irradiated or normally aged mice, and led to …

… aging, and in particular in age-related diseases of bones and joints. Here, we review age-related …
They first showed direct correlation between stem cell numbers and time to reach bone …

… , leading to hypothyroidism which is among the most frequent chronic diseases in the elderly
[86]. … to target age-related changes in BMSC to treat age-related bone fragility and risk. …