[HTML][HTML] Targeting the DNA damage response in hematological malignancies
… activity of ionizing radiation as well as the anthracycline topoisomerase II inhibitor, daunorubicin,
alone or in combination with cytarabine, in AML cell … synergize with bortezomib in this …
alone or in combination with cytarabine, in AML cell … synergize with bortezomib in this …
[PDF][PDF] Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
SPS Dhami - 2019 - aran.library.nuigalway.ie
… the AML cells against cytotoxic agents such as BH3-mimetics, cytarabine and daunorubicin.
We … Next, we investigated the mechanism through which the BMM protects the FLT3-ITD …
We … Next, we investigated the mechanism through which the BMM protects the FLT3-ITD …
[HTML][HTML] Redox control in acute lymphoblastic leukemia: from physiology to pathology and therapeutic opportunities
Y Chen, J Li, Z Zhao - Cells, 2021 - mdpi.com
… inducing the reversible multidrug resistance phenotype in ALL cells [5]… , including proteasome
inhibitors such as bortezomib and … chemotherapy agents, cytarabine and daunorubicin [3]. …
inhibitors such as bortezomib and … chemotherapy agents, cytarabine and daunorubicin [3]. …
The nuclear export protein XPO1—from biology to targeted therapy
AS Azmi, MH Uddin, RM Mohammad - Nature reviews Clinical oncology, 2021 - nature.com
… squamous cell carcinoma, which can lead to anthracycline resistance … in the emergence
of bortezomib resistance 86 . SMC1A … Anchorage-independent growth is one of the defining …
of bortezomib resistance 86 . SMC1A … Anchorage-independent growth is one of the defining …
In the Pipeline: Emerging Therapy for Acute Myeloid Leukaemia
H Gill, A Yip - Pathogenesis and Treatment of Leukemia, 2023 - Springer
… While the combination of cytarabine and anthracyclines (7 + 3… ) induces p53-independent
apoptosis upon binding to its cell … Bortezomib inhibits the 26S subunit of proteasome complex …
apoptosis upon binding to its cell … Bortezomib inhibits the 26S subunit of proteasome complex …
[HTML][HTML] Bone marrow microenvironment as a source of new drug targets for the treatment of acute myeloid leukaemia
KA Skelding, DL Barry, DZ Theron, LF Lincz - International journal of …, 2022 - mdpi.com
… transporters MDR1, multidrug resistance associated protein … initial treatment of AML (notably
anthracyclines) can have off-… decreased in vitro by the proteasome inhibitor bortezomib, or …
anthracyclines) can have off-… decreased in vitro by the proteasome inhibitor bortezomib, or …
[HTML][HTML] Ex Vivo Chemosensitivity Profiling of Acute Myeloid Leukemia and Its Correlation With Clinical Response and Outcome to Chemotherapy
Y Zhang, M Ji, JY Zhao, HF Wang, CW Wang… - Frontiers in …, 2022 - frontiersin.org
… . tested the ex-vivo drug activity of cytarabine, idarubicin, and their … sensitivity to different
anthracyclines, and every third of the … , gilteritinib, dasatinib, and bortezomib are not yet included, …
anthracyclines, and every third of the … , gilteritinib, dasatinib, and bortezomib are not yet included, …
[PDF][PDF] Effect of SHARP1 Knockdown and PLEKHA7 Re-expression on the Growth and Behavior of Acute Myeloid Leukemia Cells induced by Functional Lipid …
SAM Ali - (No Title), 2022 - nagoya.repo.nii.ac.jp
… of the potential therapeutic activity of SHARP1 knockdown using … Cytarabine and Anthracycline
combination is still regarded as a … Interactions between bortezomib and romidepsin and …
combination is still regarded as a … Interactions between bortezomib and romidepsin and …
Understanding and targeting resistance mechanisms in cancer
… Cytarabine (AraC), a nucleoside drug used in patients with … (also known as multidrug
resistance-associated proteins, MRPs… taxanes, vinca alkaloids, and anthracyclines. The spectrum …
resistance-associated proteins, MRPs… taxanes, vinca alkaloids, and anthracyclines. The spectrum …
[HTML][HTML] Treatment of multiple myeloma and the role of melphalan in the era of modern therapies—Current research and clinical approaches
… Bortezomib inhibits the expression and secretion of vascular … a sodium- and pH-independent
transporter that provides vital … Multiple drug resistance (MDR) contributes to the failure of …
transporter that provides vital … Multiple drug resistance (MDR) contributes to the failure of …