The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage

MP Murphy, DA Niedziela, FC Leonard, OM Keane - Scientific reports, 2019 - nature.com
… important disease affecting dairy cattle worldwide. … response from MAC-T cells at 1 hpi;
however, for all other time points … Lack of TLR2 stimulation in human cells transfected with bovine

Development of recombinant staphylococcal cytotoxins and superantigens as vaccine candidates against bovine mastitis caused by Staphylococcus aureus

S Yoon - 2019 - scholarsjunction.msstate.edu
… is to develop an effective vaccine to protect dairy cattle from S. … II molecules on antigen
presenting cells (APC) and to T cells with … , we demonstrated that long-term stimulation of bovine

[HTML][HTML] Relative virulence of Staphylococcus aureus bovine mastitis strains representing the main Canadian spa types and clonal complexes as determined using in …

…, A Larose, C Ster, JF Lucier, S Rodrigue, S Park… - Journal of Dairy …, 2021 - Elsevier
… both clinical and subclinical bovine mastitis in dairy cattle. Prediction of disease … superantigens
(SAg) which, when expressed by the bacterium, may stimulate one or more T lymphocyte

Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

MD Edmans, TK Connelley, S Jayaraman… - Frontiers in …, 2021 - frontiersin.org
Cattle MAIT cells were responsive to stimulation by 5-OP-RU … strain DH5α and Staphylococcus
aureus strain RF122 from … + T cells and 5-OP-RU reactive cells in cattle peripheral blood…

Staphylococcus aureus isolated from skin from atopic-dermatitis patients produces Staphylococcal enterotoxin Y, which predominantly induces T-cell receptor Vα …

F Aziz, J Hisatsune, L Yu, J Kajimura… - Infection and …, 2020 - Am Soc Microbiol
… Concurrently, the same ORF was identified in a bovine isolate of S. … Overall, we demonstrate
that SEY 2 acts as a superantigen that specifically stimulates human T cells bearing TCR Vα …

Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia

…, N Park, DE Heinrichs, L Benedictus, T Connelley… - Mbio, 2020 - Am Soc Microbiol
… (SAgs) are a family of secreted toxins that stimulate T cell … As cattle contain high levels of
γδ T cells in peripheral blood, … , suggesting that it has not evolved to stimulate bovine T cells. …

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

B Campos, AC Pickering, LS Rocha, AP Aguilar… - BMC Veterinary …, 2022 - Springer
Staphylococcal superantigens activate T-cells resulting in the … isolates of dairy cattle across
all investigated countries with … As a result, several T cells that share the same Vβ segment …

Immunoproteomic analysis of the secretome of bovine-adapted strains of Staphylococcus aureus demonstrates a strain-specific humoral response

SD Drumm, P Cormican, P O'Boyle, RA Owens… - Veterinary Immunology …, 2022 - Elsevier
repertoire of superantigens (SAg) and staphylococcal … on the subsequent immune responses
of cattle, and how this … to identify antigenic proteins that stimulate a local mucosal response …

Staphylococcal superantigens: pyrogenic toxins induce toxic shock

T Krakauer - Toxins, 2019 - mdpi.com
superantigenic toxins produced by Staphylococcus aureus … monocytes/macrophages and T
lymphocytes. The bridging of … components, and IFN-stimulated genes. This review focuses on …

Differential immune response to two Staphylococcus aureus strains with distinct adaptation genotypes after experimental intramammary infection of dairy cows

…, C Baravalle, CM Camussone, S Monecke… - Microbial …, 2022 - Elsevier
… a further immune response, mainly stimulated by strain P and … vitro studies with MAC-T
cells and bovine macrophages [16]. The … experimental IMI studies in cattle in which different S. …