… developed for humans that measures the ability to infer rules … b | Brain regions supporting
executive function and flexibility … for frontostriatal systems in mediating these behaviours 71 . A …

… brain mechanisms underlying the development of flexible cognition … (B) Example flexible
rule switch task. On color trials, participants are … of frontoparietal brain regions with age (56,57). …

… through development and aging. Our results are in line with behavioral studies of cognitive
… This finding was also replicated using more regions of interest within the M-FPN, L-FPN, and …

… with other brain regions play key … development without establishing connections between
them. Here, we review this rich body of literature, aligning major events in mPFC development …

… models of networks has developed a multilayer network … mediation analysis to elucidate
the mediating role of brain … local regions, was more likely to become an underlying mediating …

… shapes neural processing in the healthy human brain. … the decodability of task rules
also mediated behavioral benefits, … To do so, we developed a behavioral task that involved …

… , abstract rules are particularly well developed in primates 5,7,… assess cognitive flexibility in
shifting between abstract rules (… animals’ task performance beyond that mediated by stimulus–…

… From our data it is not clear whether the reduction in inhibitory drive to L5 cells will lead
to enhanced activity in downstream brain regions or whether it actually compensates for a …

… with executive performance and partially mediated age-related … and abstract rules for
executing goals. The protracted … the flexible and integrative role of these brain regions within the …

… cognition in mammalian brains. Although several association brain regions, including the …
Conversely, if mice could use task structural knowledge to infer state change upon rule …