[HTML][HTML] Brainstem pain-modulation circuitry and its plasticity in neuropathic pain: insights from human brain imaging investigations

EP Mills, KA Keay, LA Henderson - Frontiers in Pain Research, 2021 - frontiersin.org
… response is situated within the brainstem and is also crucial … anatomy and function of the
brainstem pain-modulation circuitry, … have begun to explore brainstem pain-modulation circuitry …

Presynaptic inhibition of pain and touch in the spinal cord: from receptors to circuits

A Comitato, R Bardoni - International journal of molecular sciences, 2021 - mdpi.com
… Nociceptive projection neurons are mostly located in lamina I and relay sensory information
to the brain stem and the thalamus. A subpopulation of these neurons expresses the …

Brainstem neuroimaging of nociception and pain circuitries

V Napadow, R Sclocco, LA Henderson - Pain Reports, 2019 - journals.lww.com
… extremely small groups of neurons within the brainstem responsible for discrete functions,
and it is assumed that the relatively primitive functions of these brainstem nuclei are preserved …

The hypothalamic-spinal dopaminergic system: a target for pain modulation

M Puopolo - Neural regeneration research, 2019 - journals.lww.com
… periaqueductal gray and to brainstem nuclei such as the locus … neurons ascending to the
parabrachial nucleus, a well-established spinal cord circuit for pain transmission from the spinal

Descending pain modulation: influence and impact

K Bannister - Current Opinion in Physiology, 2019 - Elsevier
… NK1-expressing projection neurons innervate various brainstem and thalamic … neurons are
retrogradely labelled from this region [4]. Unsurprisingly this translates to an impact on spinal

Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

Y Kohro, T Matsuda, K Yoshihara, K Kohno… - Nature …, 2020 - nature.com
… blockade of spinal α 1 -ARs 49 suppresses PNI-induced mechanical hypersensitivity and
that PNI changes neither the spontaneous activity of LC neurons 50 nor the spinal NE content …

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain

RG Xie, WG Chu, DL Liu, X Wang, SB Ma… - Nature …, 2022 - nature.com
… in spinal-PAG projection neurons at a holding potential of −70 mV by stimulation of the dorsal
root. Spinal-PAG projection neurons … In spinal-PAG projection neurons of wild-type mice, a …

Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats

CM Batista, ED Mariano, CS Dale… - Neural regeneration …, 2019 - journals.lww.com
… VM cells differentiated into NeuN+ neurons, with a high proportion of … neuronal precursors
from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal

The pathways and processes underlying spinal transmission of low back pain: observations from dorsal root ganglion stimulation treatment

KB Chapman, PS Groenen, KC Vissers… - … : Technology at the …, 2021 - Elsevier
… a single target location or neuron, is a hallmark of back pain transmission. Lumbar C- and
Aδ nociceptive nerve fibers arising from nerve roots of multiple spinal segments may converge …

Anatomy and Physiology: Mechanisms of Nociceptive Transmission

S Grubb, GW Pasvankas - Academic Pain Medicine: A Practical Guide to …, 2019 - Springer
… via ascending relay tracts through the spinal cord and brainstem, and modulation in primary
… to potentiate descending control of pain transmission. The noradrenergic neurons of the …