… response is situated within the brainstem and is also crucial … anatomy and function of the
brainstem pain-modulation circuitry, … have begun to explore brainstem pain-modulation circuitry …

… Nociceptive projection neurons are mostly located in lamina I and relay sensory information
to the brain stem and the thalamus. A subpopulation of these neurons expresses the …

… extremely small groups of neurons within the brainstem responsible for discrete functions,
and it is assumed that the relatively primitive functions of these brainstem nuclei are preserved …

… periaqueductal gray and to brainstem nuclei such as the locus … neurons ascending to the
parabrachial nucleus, a well-established spinal cord circuit for pain transmission from the spinal …

… NK1-expressing projection neurons innervate various brainstem and thalamic … neurons are
retrogradely labelled from this region [4]. Unsurprisingly this translates to an impact on spinal …

… blockade of spinal α 1 -ARs 49 suppresses PNI-induced mechanical hypersensitivity and
that PNI changes neither the spontaneous activity of LC neurons 50 nor the spinal NE content …

… in spinal-PAG projection neurons at a holding potential of −70 mV by stimulation of the dorsal
root. Spinal-PAG projection neurons … In spinal-PAG projection neurons of wild-type mice, a …

… VM cells differentiated into NeuN+ neurons, with a high proportion of … neuronal precursors
from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal …

… a single target location or neuron, is a hallmark of back pain transmission. Lumbar C- and
Aδ nociceptive nerve fibers arising from nerve roots of multiple spinal segments may converge …

… via ascending relay tracts through the spinal cord and brainstem, and modulation in primary
… to potentiate descending control of pain transmission. The noradrenergic neurons of the …