… evidence for antigen-driven clonal expansion in vivo and … T cell responses are broad and
heterogeneous (38, 39), we … To study HIV-1–specific cells, we used overlapping Gag peptides, …

… strategies aiming at latency reversal and T cell vaccination in … of its potentially broad
applicability, biomarkers for functional … number of HIV-1 specific CD8 + T cells decreases overtime (…

… At the same time, there was no HIV-1-specific CTL activity … Notably, PHA, as a potent mitogen,
can elicit broad cell activation … Similarly, a successful vaccine should induce CD8 + T cell …

… and therapeutic vaccines deserve robust attention on the … 37) and oligoclonal expansions of
tumor-infiltrating T cells have … growing number of high affinity broadly neutralizing antibodies …

… Broadly neutralizing antibodies (bNAbs) represent a potential … the persistent expansion of
HIVspecific Tfh cell responses … this CD4+ T cell subset in the context of vaccination. In humans…

… SIV-specific CD8 T cell responses by vaccines can attenuate … the broad range of responses
of the integrated proviruses at … that of naturally occurring HIV-1-specific CTL clones isolated …

… CAR T cells tended to have limited in vivo expansion and … T cells, was designed to redirect
CTLs by binding a broadly … using GS-986 (TLR7 agonist) and an Ad26/MVA vaccine led to …

… HLA class I through their T-cell receptor (TCR) and trigger … that focusing vaccine-elicited
T cells on the functionally conserved … HIVconsv/MDDL for their in vivo expansion (Figure 6a). …

… from expansion and contraction of infected CD4 + T cell clones. … Individuals with
vaccine-responsive T cell clones that harbor … HIV-1–specific primers and a probe targeting a …

… in frequency and acquired effector function (granzyme-B) in … by vaccine-induced clonal
expansion of HIV-infected cells. … Broad inclusion of these in future latency reversal studies will …