… CD8 T cells expressing one of three HIV-specific TCRs (TCR-… cell free spread (ie broadly
neutralizing Abs) and CAR T … of T cells were cultured in CTS OpTmizer T-cell expansion SFM(…

… as clonal expansion, where an antigen-specific CD8 T cell … of their TCR with antigen-loaded
MR1 elicits rapid and broad … drive the need for a cost-effective and efficacious vaccine, …

… The TCR on a CD8+ T cell is a heterodimer made of either a … a T cell becomes activated, it
can undergo clonal expansion … persistently driven by the large-scale depletion of CD4+ T cells …

… measured HIV-1 specific CD8+ T cells responses during … holds during CD8+ T cell
differentiation, where genome-wide … developing a broadly cross-reactive T cell-based vaccine …

… At the same time, there was no HIV-1-specific CTL activity … Notably, PHA, as a potent mitogen,
can elicit broad cell activation … Similarly, a successful vaccine should induce CD8 + T cell …

… -specific, TCR-activated non-cytolytic CD8 + T cells suppress … by a fellowship from Emory
AIDS Vaccine 200 (AV200). The … + T cells, the frequency of HIV-1-specific cytotoxic CD8 + T …

… Ultimately this impaired ability of HIV-1 specific CD8 T cells to … Cytomegalovirus vaccine
vectors were designed in the … maintain high frequency, effectordifferentiated, and broadly …

… , including broadly neutralizing antibodies, T cell vaccines, or … expansion due to homeostatic
proliferation even during ART, … node cells restored HIV-1-specific CD8+ T cell function (311). …

… We therefore hypothesized that naive human T cells would drive xenogeneic reactions and
… viral expansion reaching nearly identical mean VLs 1 wk after infection/T cell injection (Fig. …

… (by rapid expansion of virus specific CD8 + T cells), to reduce … immunotherapy and to optimize
efficiency of vaccines. … such as CD8 + T cells depletion or broadly neutralizing antibodies …