[HTML][HTML] Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
J Harre, L Heinkele, M Steffens, A Warnecke… - Frontiers in Cellular …, 2021 - frontiersin.org
… In this study, the effect of different constructs of C3 on SGN alone and … The action of different
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …
Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges
HN Noristani - Experimental Neurology, 2022 - Elsevier
… their inhibitory effects on axon regeneration. However, CNS … the DRG lack dendrites
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …
[HTML][HTML] Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration
Y Izhiman, L Esfandiari - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
… application of Clostridium botulinum C3 exoenzyme (C3), a … and promotes axonal regeneration
both in vivo and in vitro, … Despite these findings, there remains a lack of understanding …
both in vivo and in vitro, … Despite these findings, there remains a lack of understanding …
Mechanisms of axon growth and regeneration: moving between development and disease
F Bradke - Journal of Neuroscience, 2022 - Soc Neuroscience
… Live in vivo imaging further showed that on taxol treatment in … effect: the classical paradigm
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …
[HTML][HTML] Use of gene therapy in retinal ganglion cell neuroprotection: current concepts and future directions
J Rhee, KC Shih - Biomolecules, 2021 - mdpi.com
… promising results in both in vivo and in vitro models, there is … Exoenzyme C3 transferase
(C3) can inactivate Rho GTPases… , the lack of nucleus entry and therefore the lack of insertional …
(C3) can inactivate Rho GTPases… , the lack of nucleus entry and therefore the lack of insertional …
[HTML][HTML] Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury
PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
… of the lack of intrinsic CNS axon regeneration ability and … in the axonal transport of
transmembrane proteins in vivo, … with the Clostridium botulinum C3 ribosylating exoenzyme has …
transmembrane proteins in vivo, … with the Clostridium botulinum C3 ribosylating exoenzyme has …
Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
… Another study involving in vivo and in vitro TBI models showed … Exoenzyme C3 transferase
is an enzyme found in Clostridium … effect of C3 transferase in promoting axonal regeneration …
is an enzyme found in Clostridium … effect of C3 transferase in promoting axonal regeneration …
[HTML][HTML] The Effect of Cutibacterium acnes Infection on Nerve Penetration in the Annulus Fibrosus of Lumbar Intervertebral Discs via Suppressing Oxidative Stress
Z Shan, X Wang, W Zong, J Li, B Zheng… - … Medicine and Cellular …, 2022 - hindawi.com
… , axonal regeneration can be improved after peripheral nerve injury … However, there is a lack
of research on C. acnes and … acnes and its contribution to nerve growth in in vitro and in vivo …
of research on C. acnes and … acnes and its contribution to nerve growth in in vitro and in vivo …
[PDF][PDF] Nano-based drug delivery systems: Targeting to corticospinal tract neurons for controlled release of therapeutics
M Cao - 2023 - twu-ir.tdl.org
… , and release imbibed C3 transferase to increase process … in-vitro BBB, but their greater
BDNF binding and C3 transferase carrying capacity may support comparable axon regeneration …
BDNF binding and C3 transferase carrying capacity may support comparable axon regeneration …
Strategies to neutralize RhoA/ROCK pathway after spinal cord injury
… lacking p75NTR, it has been found to have a reduced axonal … RGM is found in vivo in structures
that direct axons by … RhoA, such as using C3 exoenzyme or overexpression of dominant-…
that direct axons by … RhoA, such as using C3 exoenzyme or overexpression of dominant-…