Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling
… We report 906 and 124 potential protein substrates targeted by caspase-3 and caspase-9,
respectively. These substrates were observed using a subtiligase-based reverse N-…
respectively. These substrates were observed using a subtiligase-based reverse N-…
CASP9 as a prognostic biomarker and promising drug target plays a pivotal role in inflammatory breast cancer
M Zhang, K Wu, M Wang, F Bai… - International Journal of …, 2022 - Wiley Online Library
… The expression of CASP9 protein was associated with prognosis and immune cells infiltration
of … , CASP9 can be used as a prognostic biomarker and a novel therapeutic target in IBC. …
of … , CASP9 can be used as a prognostic biomarker and a novel therapeutic target in IBC. …
Pyroptosis‐related molecular classification and immune microenvironment infiltration in breast cancer: A novel therapeutic target
J Luo, J Lai - Journal of cellular and molecular medicine, 2022 - Wiley Online Library
… Upregulation of CASP9 by miR-182-5p inhibition can induce … Similarly, upregulation of
CASP9 through NF-κB contributed … of CASP9 by microRNA-224 37 or inactivation of CASP9 by …
CASP9 through NF-κB contributed … of CASP9 by microRNA-224 37 or inactivation of CASP9 by …
Caspase‐9 acts as a regulator of necroptotic cell death
… -9 provides a promising therapeutic target to manipulate the … have been discovered and
classified and these cell death … RIPK3, or pLENTI-Casp9 lentiviral backbone vector together …
classified and these cell death … RIPK3, or pLENTI-Casp9 lentiviral backbone vector together …
Investigation of caspase 9 gene polymorphism in patients with non-small cell lung cancer
S Ercan, S Arinc, SG Yilmaz, C Altunok… - Anticancer …, 2019 - ar.iiarjournals.org
… cysteine residues from aspartate residues in target proteins (4). CASP9, a member of that …
CASP9 allele variation carriers had lower CASP9 levels and apoptotic capacity, therefore …
CASP9 allele variation carriers had lower CASP9 levels and apoptotic capacity, therefore …
A novel classification model for lower-grade glioma patients based on pyroptosis-related genes
Y Shen, H Chi, K Xu, Y Li, X Yin, S Chen, Q Yang, M He… - Brain Sciences, 2022 - mdpi.com
… targeted therapy and immunotherapy for patients with LGG. … This mutation generated a
short CASP9 isoform and may disrupt the … Our study indicated that CASP9 overexpression was …
short CASP9 isoform and may disrupt the … Our study indicated that CASP9 overexpression was …
To split or not to split: CASP15 targets and their processing into tertiary structure evaluation units
A Kryshtafovych, DJ Rigden - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
… by Nick Grishin and coworkers in CASP9. They argued that targets should … In previous CASPs,
EUs were classified into difficulty … automated approaches to target classification, aiming to …
EUs were classified into difficulty … automated approaches to target classification, aiming to …
A review on caspases: key regulators of biological activities and apoptosis
G Sahoo, D Samal, P Khandayataray… - Molecular neurobiology, 2023 - Springer
… Caspases have been broadly classified by their known roles … active site that attacks a target
protein after an aspartic acid … Caspase-9 is an initiator caspase encoded by the CASP9 gene …
protein after an aspartic acid … Caspase-9 is an initiator caspase encoded by the CASP9 gene …
Exogenous introduction of initiator and executioner caspases results in different apoptotic outcomes
F Anson, S Thayumanavan, JA Hardy - JACS Au, 2021 - ACS Publications
… Apoptotic caspases are classified as either upstream initiator … Delivered active casp-6,
casp-7, casp-9, and casp-9 cD were … to casp-9 NGs, the delivery efficiency of casp-9 increased (…
casp-7, casp-9, and casp-9 cD were … to casp-9 NGs, the delivery efficiency of casp-9 increased (…
Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients
L Lykowska-Szuber, M Walczak… - Journal of Applied …, 2023 - Springer
… We aim to investigate the impact of the caspase 9 (CASP9) … The sequence of the CASP9
gene was analyzed using next-… Using the RT-qPCR analysis, we estimated the CASP9 gene …
gene was analyzed using next-… Using the RT-qPCR analysis, we estimated the CASP9 gene …