Immunobiology and conflicting roles of the human CD161 receptor in T cells

Ł Wyrożemski, SW Qiao - Scandinavian Journal of Immunology, 2021 - Wiley Online Library
is encoded by KLRB1 located within the natural killer cell (NKC) gene complex on
chromosome 12. CD161 is expressed on the majority of natural killer (NK) … of various pro-inflammatory

… in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells

EM Walker, N Slisarenko, GL Gerrets, PJ Kissinger… - Geroscience, 2019 - Springer
… in the different groups … pro-inflammatory environment observed in older individuals. Notably,
in addition to the shrinking of the CD161-expressing subsets of CD4 T, CD8 T, and NK cells

High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo-and autoimmunity

T Erkers, BJ Xie, LJ Kenyon, B Smith… - Blood, The Journal …, 2020 - ashpublications.org
… KLRD1 (CD94) is a killer cell lectin–like receptor that is … whether the CD94 + phenotype is
more pro-inflammatory or anti-… study is that there is an increase in HLA-II + CD161 – iNKT cells

[HTML][HTML] The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
… NK cells have distinct subsets with disparate developmental … The time series of CD161,
NKG2D and NKp46 makes the … in the synovium could abundantly produce pro-inflammatory

[HTML][HTML] On the way to become a natural killer cell

C Di Vito, J Mikulak, D Mavilio - Frontiers in immunology, 2019 - frontiersin.org
… ) NK cell subset producing high amount of pro-inflammatory … that are phenotypically and
functionally distinct from their … pos /CD161 pos phenotype defines mature NK cells that can be …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
cell-surface markers can aid in identifying NK cell subsets in … of inhibitory receptors such as
CD161 117 and NKG2A, 119 or … by producing other pro-inflammatory mediators. Reciprocal …

Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56dimCD16bright natural killer cells during kidney allograft antibody–mediated rejection showing a …

E Bailly, C Macedo, J Ossart, K Louis, X Gu… - Kidney International, 2023 - Elsevier
… heterogeneous natural killer (NK) cell subsets involved in … CD161 expression marks
pro-inflammatory NK cells with … CD16 bright natural killer (NK) cell frequency is associated with …

The proportion of CD161 on CD56+ NK cells in peripheral circulation associates with clinical features and disease activity of primary Sjögren's syndrome

P Zhao, Y Yang, S Song, W Cheng… - Immunity …, 2024 - Wiley Online Library
… the proportion of CD161 on CD56 + natural killer (NK) cells in … is called NK cell receptor
protein 1A (NKR-P1A) or killer cell … and pro-inflammatory cytokines TNF-α and IFN-γ on CD161

Changes of frequency and expression level of CD161 in CD8+ T cells and natural killer T cells in peripheral blood of patients with systemic lupus erythematosus

Y Park, J Lim, SY Kim, GC Kwon… - Microbiology and …, 2020 - Wiley Online Library
… receptor protein 1A (NKR-P1A), killer cell lectin-like receptor … that CD161 was a marker of
pro-inflammatory NK cell function … The MFIs of CD161 + cells of each lymphocyte subset were …

[HTML][HTML] Human gut-associated natural killer cells in health and disease

A Poggi, R Benelli, R Venè, D Costa, N Ferrari… - Frontiers in …, 2019 - frontiersin.org
… It is not clear whether these two NK cell subsets derive from … It is still unknown whether
CD161 also plays a role in the … increased secretion of the pro-inflammatory cytokines IFNγ TNFα …