… to explore the role of CREB in synaptic plasticity and memory formation in vertebrate … CREB
showed impaired memory formation in contextual fear conditioning, and the spatial memory …

… factor (BDNF) are the main target genes for memory consolidation and LTP regulated by
CREB. CREB also controls neurogenesis by regulating the expression of BDNF or PSA-NCAM …

… In addition, the participation of transcription mediated by CREB has been widely analyzed
in the memory process and AD development. Designing pharmacologic or genetic therapeutic …

… memory, similar to overexpressing wild-type CREB for 2–3 d before training [23]. This finding
indicates that high CREB … to govern allocation and enhance memory. In contrast, increasing …

… long-term memory and here we show that selective disruption of CREB phosphorylation in
… recognition memory, object temporal order memory, and spatial temporal order memory. In …

… neurons to promote memory consolidation 22. CREB is phosphorylated through this …
that PHF2 enhanced memory formation through the BDNF–TrkB‐CREB signaling pathway (…

… , CREB seems to have at least two roles in memory consolidation: first, it functions as an
on-switch for plasticity depending on a broad range of signals; second, it is a TF for memory …

… Hence, we hypothesized that ASP could ameliorate memory impairment through activating
BDNF/TrkB/CREB pathway in AD rat. To confirm the hypothesis above, K252a (an inhibitor of …

… We hypothesize that ERK–CREB might be involved in the formation of neuronal plasticity,
thereby affecting the ability of learning and memory. Therefore, we tested ERK and CREB …

… memory expression. Together, our data demonstrate that memory consolidation by mPFC
engram cells requires CREB-… functionality of this network hub being gated by memory strength. …