Fractalkine/CX3CL1 in neoplastic processes

J Korbecki, D Simińska, K Kojder, S Grochans… - International journal of …, 2020 - mdpi.com
… involved in the anticancer function of lymphocytes—mainly NK cells, T … apoptotic bodies
contain factors causing chemotaxis of phagocytic cells, mainly the chemotaxis of macrophages

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

D Szukiewicz - International journal of molecular sciences, 2024 - mdpi.com
… inducing the adhesion and chemotaxis of leukocytes, FKN has anti-apoptotic effects and …
macrophage polarization in colorectal cancer. Therefore, the silencing of CX3CR1 may promote

Fractalkine (CX3CL1) and its receptor CX3CR1: a promising therapeutic target in chronic kidney disease?

S Cormican, MD Griffin - Frontiers in immunology, 2021 - frontiersin.org
… survival and increased apoptotic monocytes within atherosclerotic … -renal macrophage
infiltration while lymphocyte and neutrophil … and demonstrated increased chemotactic potency for …

CX3CL1 signaling in the tumor microenvironment

MJ Conroy, J Lysaght - … Microenvironment: The Role of Chemokines–Part …, 2020 - Springer
… , in which it primarily functions as a chemotactic cytokine [1]. … macrophages in the liver
implicating it in macrophage-… and higher density of tumor-infiltrating lymphocytes (TILs) [38]. …

[HTML][HTML] Regulation and biological functions of the CX3CL1-CX3CR1 axis and its relevance in solid cancer: A mini-review

S Rivas-Fuentes, A Salgado-Aguayo… - Journal of …, 2021 - ncbi.nlm.nih.gov
… is chemotactic for several cell types, such as T lymphocytes, … with a transgenic macrophage
Fas-induced apoptosis mouse … a greater recruitment of lymphocytes or macrophages 103 . …

The impact of the CX3CL1/CX3CR1 axis in neurological disorders

P Pawelec, M Ziemka-Nalecz, J Sypecka, T Zalewska - Cells, 2020 - mdpi.com
… CX3CL1 adhesive and chemotactic isoforms are mediated … , promote the activation of microglia
and stimulate the release … the peripheral immune system (macrophages, mast cells, and …

CX3CR1–fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases

FR Greiffo, V Viteri-Alvarez… - European …, 2020 - Eur Respiratory Soc
… This CX3CR1 + CD68 + macrophage transitions into an … The CX3CL1/fractalkine is
identified as “find-me signal”, from … In conclusion, this study identified a chemotactic gradient of …

Fractalkine Signalling (CX3CL1/CX3CR1 Axis) as an Emerging Target in Coronary Artery Disease

SX Loh, Y Ekinci, L Spray, V Jeyalan, T Olin… - Journal of Clinical …, 2023 - mdpi.com
… Within the tissue, the leukocytes follow a chemotactic … myocarditis have abundant T
lymphocytes and macrophages [86]… abundance of virus-specific cytotoxic T lymphocytes, we found …

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

MS Subbarayan, A Joly-Amado, PC Bickford… - Pharmacology & …, 2022 - Elsevier
… CX3CL1 stimulation of primary microglia and BV2 cells … The soluble CX3CL1 (sCX3CL1)
functions as a chemotactic … increased infiltration of peripheral macrophages and upregulation of …

Comparative analysis of the occurrence and role of CX3CL1 (fractalkine) and its receptor CX3CR1 in hemophilic arthropathy and osteoarthritis

P Wojdasiewicz, ŁA Poniatowski… - Journal of …, 2020 - Wiley Online Library
Macrophages consist of cells that express CX3CR1 and are sensitive to the chemotactic
This specific subpopulation lymphocytes cause the rapid apoptosis of target cells resulting …