[HTML][HTML] Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes
JWH Leow, Y Gu, ECY Chan - European Journal of Pharmaceutical …, 2023 - Elsevier
… deuterated dronedarone also mitigated drug-induced proarrhythmia in spontaneously beating
cardiomyocytes and canine model of persistent atrial fibrillation compared to dronedarone …
cardiomyocytes and canine model of persistent atrial fibrillation compared to dronedarone …
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
… In this review, we discuss CYP2J2-mediated metabolism of AA in the heart with a focus
on … well as inhibition and inactivation of its activity by xenobiotics. The role of CYP2J2-mediated …
on … well as inhibition and inactivation of its activity by xenobiotics. The role of CYP2J2-mediated …
Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib
… the typical and atypical inhibition kinetics of CYP2J2 by ibrutinib and osimertinib. The …
dronedarone treatment or CYP2J2 knockdown in human cardiomyocytes resulted in proarrhythmia …
dronedarone treatment or CYP2J2 knockdown in human cardiomyocytes resulted in proarrhythmia …
… drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches …
LWT Tang, ECY Chan - Biochemical Pharmacology, 2022 - Elsevier
… discoveries on the arcane metabolic activation pathways of … potent irreversible inhibition of
CYP2J2 elicited by dronedarone … mitochondrial toxicity and proarrhythmia in cardiomyocytes […
CYP2J2 elicited by dronedarone … mitochondrial toxicity and proarrhythmia in cardiomyocytes […
Identification of infigratinib as a potent reversible inhibitor and mechanism-based inactivator of CYP2J2: nascent evidence for a potential in vivo metabolic drug-drug …
… the previously arcane reversible inhibition and TDI of CYP2J2-mediated … (ie, proarrhythmic)
propensities via the inhibition of … agent dronedarone that potently inactivated the CYP2J2-…
propensities via the inhibition of … agent dronedarone that potently inactivated the CYP2J2-…
Atypical kinetics of cytochrome P450 2J2: epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors
… dronedarone (0.25 μM), an established competitive inhibitor … the mode of inhibition and
potency of CYP2J2 inhibition for … Drugs which exhibited similar mode of inhibition against CYP2J2…
potency of CYP2J2 inhibition for … Drugs which exhibited similar mode of inhibition against CYP2J2…
… Growth Factor Receptor Inhibitors by Cytochrome P450: Mechanistic Investigations into the Biochemical Basis and Pharmacokinetic Implications of Mechanism …
LWT Tang - 2022 - search.proquest.com
… In this thesis, we deciphered the arcane metabolic activation pathways of an emerging class
of tyrosine kinase inhibitors known as the fibroblast growth factor receptor (FGFR) inhibitors …
of tyrosine kinase inhibitors known as the fibroblast growth factor receptor (FGFR) inhibitors …