… , which play a role in regulating kidney inflammation and fibrosis. In this review, we focus
on … focus on the NLRP3 inflammasome in kidney diseases both in canonical and non-canonical …

… 1 activity, the non-canonical NLRP3 inflammasome induces caspase-8… the NLRP3
inflammasome in chronic renal injury and fibrosis … We demonstrated canonical NLRP3 …

… The canonical NLRP3–ASC–caspase-1–IL-1β–IL-18 axis … find any difference in renal
inflammation and fibrosis in Nlrp3-deficient … NLRP3 inflammasome activation and subsequent …

… Classically, the canonical activation of NLRP3 inflammasome … occurring direct activation of
non-canonical caspases. Since … renal fibrosis observed robust activation of canonical NLRP3 …

… via caspase-1 is defined as a canonical pathway. However, a … caspase-1 is classified as
the non-canonical inflammasome. … NLRP3 inflammasome, and the renal expression of NLRP3 …

… activation of the canonical NLRP3 inflammasome for cytokine … stimulated by canonical
NLRP3, AIM2 and NLRC4-dependent … NLRP3 is also able to promote fibrosis in other cell types …

… Nevertheless, the role of NLRP3 in fibrosis development has … mentioned fibrosis pathway
with the NLRP3 inflammasome … is shown in its canonical and non-canonical forms. The …

… NLRP3 inflammasome plays an important role in inducing renal inflammation and fibrosis.
Small molecule inhibitors targeting the NLRP3 inflammasome are potential agents for the …

… The activation pathways of NLRP3 inflammasome include canonical activation pathway
and non-canonical activation pathway. As aforementioned, after the combination of the …

… In conclusion, ropinirole has the potential to be a reno-therapeutic treatment against I/R insult
by abating the inflammatory NLRP3 inflammasome signal, pyroptosis, and oxidative stress. …