… The developed disease models were successful in predicting captopril PK … parameters
were in close agreement. The developed captopril PBPK models can assist in tailoring captopril …

… -disease model of captopril 32 was scaled to the pediatric population for estimating captopril
ADME in children with renal impairment. The study aimed to predict captopril PK in children …

… It is more prevalent in the elderly population. Recently updated American and European
guidelines recommend treating every elderly patient with hypertension independent of age, …

… Many categories of drugs are used today for hypertension such as captopril which belongs
to ACE inhibitors family and hydrochlorothiazide which consider a diuretic drug.In this …

… the first-line treatment in pediatric heart failure and is together with captopril the most widely
… were informative in terms of the pharmacokinetic parameters, enalapril concentrations in the …

… regarding pharmacological treatment (including new approaches in HF treatment strategies
[… sex differences) and treatment (pharmacokinetic and pharmacodynamic changes in drugs; …

… dosing is usually sufficient for BP control except for captopril (requiring at least 2–3 doses
per … Table 40.2 Pharmacokinetic characteristics and dosage of selected angiotensin receptor …

… include verapamil, captopril, felodipine, and … it does exhibit a protective effect against stroke
[39,40,41]. These sex differences may be attributed to the distinct pharmacokinetic properties …

… can improve the pharmacodynamic and pharmacokinetic properties of biopharmaceuticals.…
Gastro-retentive drug delivery systems and their in vivo success: A recent update. Asian J …

… studied, and captopril was the first … Captopril possesses a sulphydryl group which forms an
ionic bond with the zinc atom. Unfortunately, although a very effective ACE inhibitor, captopril …