Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …

… Mammalian carboxylesterases (CES) are one important class of serine hydrolases that …
At present, the crystal structures of several mammalian carboxylesterases including hCES1A …

Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are among the
most abundant hydrolases in humans, catalyzing the metabolism of numerous clinically …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%–95…

… progress in human carboxylesterases (hCEs) mediated herb-drug interactions (HDIs). The
key roles of hCEs in drug metabolism, the inhibitory capacities and inhibition mechanism of a …

… functional group by carboxylesterase enzymes. The product … As it was mentioned above,
carboxylesterase (CES) enzymes … as a potent selective inhibitor of both carboxylesterases (52, …

… The current study has 2 goals: (1) to investigate the potential in vitro inhibition of purified
human hepatic carboxylesterase (hCE1) by ITP and TBPP isomers and related flame retardant …

… This manuscript provides a meta-analysis of human variability associated with
carboxylesterase activities and kinetic parameters for well-characterised probe substrates using …

… discover efficacious CES2 inhibitors from natural products and to characterize the inhibition
potentials and inhibitory mechanisms of the newly identified CES2 inhibitors. Following high-…

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …