[HTML][HTML] Anticancer properties of carnosol: a summary of in vitro and in vivo evidence

EJ O'Neill, DJ Den Hartogh, K Azizi, E Tsiani - Antioxidants, 2020 - mdpi.com
Carnosol (Figure 1) is an ortho-diphenolic diterpene that … In the control group, mice started
showing papillomata at 6 … breast cancer, prostate cancer, and skin cancer cells with carnosol

An overview of the chemistry and anticancer properties of rosemary extract and its diterpenes

EWC Chan, SK Wong, HT Chan - Journal of Herbmed …, 2021 - herbmedpharmacol.com
… of extracts and diterpenes (carnosic acid, carnosol, and rosmanol) of rosemary. Emphasis is
on colon and prostate cancer cells. … Carnosol, a dietary diterpene, displays growth inhibitory

[HTML][HTML] Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol

S Habtemariam - Biomedicines, 2023 - mdpi.com
… of the two most abundant rosemary diterpenes, carnosic acid (CA) and carnosol (CAR), …
that CA displayed antiproliferative and cancer metastasis inhibitory effects by inhibiting the ERK, …

[HTML][HTML] Inhibition of Prostate Cancer Cell Survival and Proliferation by Carnosic Acid Is Associated with Inhibition of Akt and Activation of AMPK Signaling

M Nadile, NSK Sze, VA Fajardo, E Tsiani - Nutrients, 2024 - mdpi.com
diterpene carnosic acid (CA), contained in RE, has significant inhibitory effect on lung cancer
… with our previous findings in lung cancer cells showing increased expression of sestrin-2 …

EFFECT OF CARNOSOL ON G PROTEIN-COUPLED RECEPTOR SIGNALING IN CANCER CELLS

LJA Abudawood - 2022 - scholarworks.uaeu.ac.ae
… first to screen various receptors for their targeting by carnosol, … a variety of cancers such as
Breast and Prostate cancer, Alzheimer’… Carnosol, a tricyclic phenolic diterpene, is a secondary …

Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells

D Termini - 2022 - dr.library.brocku.ca
… stages (castration-resistant prostate cancer- CRPC) is often … the dysregulated mechanisms
in prostate cancer. In some studies, … diterpenes in rosemary are carnosic acid and carnosol (…

Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia

S Lu, Y Li, Q Shen, W Zhang, X Gu… - Journal of cachexia …, 2021 - Wiley Online Library
Carnosol (CS) is a bioactive diterpene compound present in … cancer patients, more than 50%
of cancer patients display … 3D, CS could partly increase the food intake of mice bearing C26 …

Antioxidant and Antiproliferative Activities of Bioactive Compounds Contained in Rosmarinus officinalis Used in the Mediterranean Diet

M Bourhia, FE Laasri, H Aourik… - Evidence‐Based …, 2019 - Wiley Online Library
… The phenolic diterpenes like carnosol and carnosic acid are … It was very important to screen
the carnosol and carnosic acid in … The carnosic acid dosed in the studied plant in the current …

Pharmacokinetic characterization of carnosol from rosemary (Salvia Rosmarinus) in male C57BL/6 mice and inhibition profile in human cytochrome P450 enzymes

B Vemu, R Tocmo, MC Nauman, SA Flowers… - Toxicology and Applied …, 2021 - Elsevier
dietary diterpenes with carnosol as one of the major polyphenols used to standardize rosemary
extracts approved as a food … /kg body weight in rats carnosol displayed a C max of 216.56…

[HTML][HTML] Carnosol, a natural polyphenol, inhibits migration, metastasis, and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3

H Alsamri, H El Hasasna, Y Al Dhaheri, AH Eid… - Frontiers in …, 2019 - frontiersin.org
… that carnosol, a naturally occurring diterpene, inhibited in … first report which shows that
carnosol specifically targets signal … with similar potency to that of carnosol in food additives (52). …