[HTML][HTML] A review on machine learning approaches and trends in drug discovery

P Carracedo-Reboredo, J Liñares-Blanco… - Computational and …, 2021 - Elsevier
… Neural Network Model, and from that moment these models … uses a graphical attention
mechanism to learn from relevant drug … It is therefore essential to study toxicological properties as …

[图书][B] Biomarkers in toxicology

RC Gupta - 2019 - books.google.com
systems. This revised and completely updated edition includes both vertebrate and non-vertebrate
species models for toxicological testing … all aspects of toxicology biomarkers Includes …

[HTML][HTML] Synthesis and Toxicity of Graphene Oxide Nanoparticles: A Literature Review of In Vitro and In Vivo Studies

A Rhazouani, H Gamrani, M El Achaby… - BioMed Research …, 2021 - hindawi.com
toxicity of GO in cellular models and biological systems. Moreover, we mention the general
mechanism of its toxicity… Finally, we showed the general mechanism of toxicity, to better …

[HTML][HTML] Uncovering the complexity mechanism of different formulas treatment for rheumatoid arthritis based on a novel network pharmacology model

K Wang, Y Gao, C Lu, Y Li, B Zhou, X Qin… - Frontiers in …, 2020 - frontiersin.org
… In this study, network pharmacology model was applied to analyze the key gene network
Moreover, it abstracts the interaction between drugs and target genes into a network model

[HTML][HTML] The NCATS BioPlanet–an integrated platform for exploring the universe of cellular signaling pathways for toxicology, systems biology, and chemical genomics

R Huang, I Grishagin, Y Wang, T Zhao… - Frontiers in …, 2019 - frontiersin.org
… Molecular pathways are defined not only by their importance in … toxicological endpoints
may potentially be caused by dysfunction of any pathway operative in human cells, mechanistic

Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects

B Le Dare, V Lagente, T Gicquel - Drug metabolism reviews, 2019 - Taylor & Francis
… This sterile inflammation mechanism may override ethanol’s beneficial effects on the immune
system and accentuate its toxicity. Furthermore, purinergic receptors (which are also able …

[图书][B] Nutraceuticals: efficacy, safety and toxicity

RC Gupta, R Lall, A Srivastava - 2021 - books.google.com
role of hormesis in neuroprotection 5 Modulation of the Nrf2-ARE pathway as a mechanism
of … 2 as a potential novel mechanism of quercetin neuroprotection 6 The issue of metabolites …

In-silico modeling in drug metabolism and interaction: Current strategies of lead discovery

H Roy, S Nandi - Current Pharmaceutical Design, 2019 - ingentaconnect.com
… (ADME) as well as toxicity studies which take 5-15 years with the … PBPK modeling is a
mechanistic approach that has been … Dmitry et al. developed a neural network model for an early …

Computational network biology: data, models, and applications

C Liu, Y Ma, J Zhao, R Nussinov, YC Zhang, F Cheng… - Physics Reports, 2020 - Elsevier
studying the biological systems from network biology has attracted much attention in recent
years, and networks have long been central to our understanding of biological systems, in …

[HTML][HTML] Pesticides and pollinators: A socioecological synthesis

DB Sponsler, CM Grozinger, C Hitaj, M Rundlöf… - Science of the Total …, 2019 - Elsevier
… literature and providing empirical case studies. We then propose … engagement, (2) mechanistic
study of pesticide exposure, (3) … , toxicological, and ecological dimensions of the system. …