Frontiers | A potential new pathway for heparin treatment of sepsis-induced lung injury:
inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 …

… molecular mechanisms underlying endothelial dysfunction and … Thus, we hypothesized that
caspase-11–mediated pyroptosis … and endotoxemia-induced endothelial pyroptosis through …

… , pyroptosis and acute lung injury and to provide the latest research progress on the
underlying … the expression of caspase-11 in mouse endothelial cells via TLR4 and then induce …

… exacerbate underlying lung injury in an iatrogenic pathology of ventilator induced … caspase-11
mediated pyroptosis, an inflammatory programmed cell death, in pulmonary endothelium …

… , dendritic cells, and endothelial cells when associated with … that caspase-11-mediated
epithelial pyroptosis is an … ideal model for experimental endotoxemia-induced kidney injury and is …

… inflammation and ALI by downregulating caspase-1 and caspase-11, which mediate
pulmonary EC pyroptosis. These findings suggest a novel strategy for the treatment of ALI. …

… the destruction of epithelial and endothelial barriers, which … caspase-11 domain and mediated
pyroptosis 12 , 13 . Hence, it is necessary to determine whether caspase-1 or caspase-11 …

… The airway epithelium and underlying innate immune cells … 3 exhibited less caspase-11-mediated
pyroptosis in response … -activate caspase-11, leading to LPS induced lung injury and …

… pyroptosis and ALI is limited. Reportedly, caspase-11 knockout and endothelial-specific
caspase-11 knockout can reduce mortality from endotoxic shock and alleviate lung damage …

… pyroptosis will help to protect epithelial and endothelial cells from damage. Caspase-11-mediated
pyroptosis occurs in lung … -out attenuates infection-induced lung injury.[82] Meanwhile, …