… interplay with the epidermal growth factor receptor (EGFR), and we … modulation of these
signaling pathways in cancer … with EGFR mutations, and that the efficacy of combined celecoxib …

… the role of EGFR in the development of colon cancer. We will … Celecoxib is shown to
induce phosphorylation of ERk1/2, … tumorassociated fibroblasts, promoting EGFR binding and …

… 2 synthesis in the cancer-associated fibroblasts could only be … modulate the adhesive
properties of intestinal cells [93] and … , combination of celecoxib with erlotinib (an EGFR tyrosine …

… , and that was reflected on the downstream signaling pathways … modulation of PI3K/AKT
pathway activity were linked [7,28-30]. … , Celecoxib suppressed the activation of the early growth …

… , such as cancer-associated fibroblasts, tumor-associated … , which target the epidermal growth
factor receptor (EGFR) [26,27]… can modulate a hypoxic TME by increasing oxygen release. …

… mechanisms underlying Celecoxib's modulation of the IGF-… which Celecoxib exerts its
inhibitory effects on IGF-1R signaling. … growth factor receptor 2-overexpressing breast cancer cells …

… Growth Factor (EGF) and Amphiregulin (AREG) Induction We previously reported the ability
of celecoxib to modulate the EGFR-AR signaling in … colorectal cancer-associated fibroblasts …

… that includes cancer-associated fibroblasts, inflammatory cells, … with the epidermal growth
factor receptor (EGFR) and Met … Celecoxib, we treated SW480 and LoVo human colorectal …

… All the CRC-TAF reported in this study expressed EGFR on their surface, while the epithelial
marker EPCAM was negative (Figure S3, two representative cases in panel A, 20 cases in …

… Epidermal growth factor (EGF)-induced EGFR tyrosine kinase … of EGFR on the surface of
cancer cells, regulating its downstream signaling is crucial for modulating cancer cell growth …