Inference of single-cell phylogenies from lineage tracing data using Cassiopeia

MG Jones, A Khodaverdian, JJ Quinn, MM Chan… - Genome biology, 2020 - Springer
… simulation parameters (as determined by the experimental data… CRISPR-recorders, our
results suggest that with adequate … size distribution described in the manufacturer’s protocol. …

SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data

H Zafar, N Navin, K Chen, L Nakhleh - Genome research, 2019 - genome.cshlp.org
score for k-medoids clustering of the cells based on a distance matrix obtained from the inferred
cell lineage tree… As the values of the error rate parameters α, β and the parameters of the …

Phylodynamics for cell biologists

T Stadler, OG Pybus, MPH Stumpf - Science, 2021 - science.org
cell lineages within tissues and organisms. Large amounts of … to infer dynamical behavior
from experimental single-cell data. … parameters can be inferred by use of standard statistical …

Characterization of cell fate probabilities in single-cell data with Palantir

M Setty, V Kiseliovas, J Levine, A Gayoso… - Nature …, 2019 - nature.com
… is also used to infer terminal states from the data. Palantir … Our results suggest continuity in
early hematopoietic lineage … with different parameters and the robustness of the results was …

Inferring population dynamics from single-cell RNA-sequencing time series data

DS Fischer, AK Fiedler, EM Kernfeld, RMJ Genga… - Nature …, 2019 - nature.com
… robustness of the parameter estimation in multiple simulation … z-scores of sliding window
expression estimates across cell … of the drift parameter on the T-cell lineage across cell state (…

A comparison of single-cell trajectory inference methods

W Saelens, R Cannoodt, H Todorov, Y Saeys - Nature biotechnology, 2019 - nature.com
inference approaches analyze genome-wide omics data … of single cells and computationally
infer the order of these cells … has a parameter γ, which was fixed at 0.1 to make the scores

Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells

Z Cao, R Grima - Proceedings of the National Academy of …, 2020 - National Acad Sciences
… A recent application of the model is its use to infer the promoter-… to a forward lineage, ie,
either of the two daughter cells is … (A) Using parameters typical of mammalian cells, we find that …

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

K Chkhaidze, T Heide, B Werner… - PLoS computational …, 2019 - journals.plos.org
… Our results indicate that spatial constrains can introduce … the ancestral history of cancer
cell lineages [6]. However, one … For Fig 4 and parameter inference framework with single cell

A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution

JS Packer, Q Zhu, C Huynh, P Sivaramakrishnan… - Science, 2019 - science.org
… in gene expression can result in discontinuous trajectories. Thus… parameters. Finally, for most
discontinuous trajectories, … above analysis, we find that the extent to which lineage predicts …

Lineage tracing meets single-cell omics: opportunities and challenges

DE Wagner, AM Klein - Nature Reviews Genetics, 2020 - nature.com
… The challenge of data analysis is then to infer the continuum … the results of more powerful
forms of data analysis. … 5 we have detailed two parameters that can strongly influence the …