Fungal cell wall: emerging antifungals and drug resistance

SL Lima, AL Colombo… - Frontiers in microbiology, 2019 - frontiersin.org
… The alternative carbon sources in the infection site change the cell wall β-D-glucan and …
relationship between the cell wall mannans of Candida albicans and Candida parapsilosis. …

Genomewide elucidation of drug resistance mechanisms for systemically used antifungal drugs amphotericin B, caspofungin, and voriconazole in the budding yeast

C Balkan, I Ercan, E Isik, E Sahin Akdeniz… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
cell membrane and have roles in lipid dynamics. Additionally, antifungal drugs mainly target
the plasma membrane … of the mutants was correlated with changes in intracellular pH. When …

Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B

C Jia, J Zhang, Y Zhuge, K Xu, J Liu, J Wang… - Free Radical …, 2019 - Taylor & Francis
… and GdA using azoles- and amphotericin B-resistant C. … to a change in membrane fluidity
[Citation9], and cause cell-cycle … the mitochondrial membrane potential, cell membrane integrity …

The yeast, the antifungal, and the wardrobe: a journey into antifungal resistance mechanisms of Candida tropicalis

JS Oliveira, VS Pereira… - Canadian Journal of …, 2020 - cdnsciencepub.com
… in the cell wall thickness may also be associated with amphotericin B resistance in C. …
sterol changes in two isolates of Candida tropicalis from a patient with an amphotericin B-resistant

Optimum Inhibition of Amphotericin-B-Resistant Candida albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids

HFZ Touil, K Boucherit, Z Boucherit-Otmani, G Kohder… - Biomolecules, 2020 - mdpi.com
… The anti-biofilm activity of terpenoids may be attributed to membrane damage, as well as …
changes in membrane permeability and fluidity can result in the degradation of cell walls, and …

Emerging role of sphingolipids in Amphotericin B Drug Resistance

K Madaan, VK Bari - Microbial Drug Resistance, 2023 - liebertpub.com
Cell wall changes in amphotericin B-resistant strains from Candida tropicalis and relationship
with the … Change of cell wall chitin content in amphotericin B resistant Kluyveromyces …

Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles

W Chan, FWN Chow, CC Tsang, X Liu… - Emerging Microbes & …, 2022 - Taylor & Francis
… in up to 16-fold changes of minimum inhibitory concentration. … cerevisiae EVs included a
number of cell wall modification … EVs isolated from an amphotericin B-sensitive strain of C. …

ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait

S Ahmad, L Joseph, JE Parker… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
… The phylogenetic relationship among the isolates was … , the evolution of amphotericin B-resistant
strains is expected … Since polyenes extract ergosterol from the cell membrane, changes

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

KM Czajka, K Venkataraman, D Brabant-Kirwan… - Cells, 2023 - mdpi.com
… -nucleotide changes occurring in Candida strains do not … of amphotericin B-resistant
Candida clinical strains suggests … Fungal cells can compensate for and strengthen the cell wall

Amphotericin B and other polyenes—Discovery, clinical use, mode of action and drug resistance

H Carolus, S Pierson, K Lagrou, P Van Dijck - Journal of Fungi, 2020 - mdpi.com
… and alterations of the fungal cell wall. In 1999, Seo et al. [76… cell wall was suggested to be
an important mechanism contributing to this resistance. The main change in the fungal cell wall