Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrous-tissue content is increased in patients with pAF and atrial scarring correlates
with … At the same time, spontaneous atrial ectopic activity seems to be an important trigger for …

Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review

KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
… is critical in triggering DADs and thus increased atrial ectopic activity. In human AF models,
… fibroblasts and epicardial adipose tissue (EAT) are positively correlated with atrial fibrosis …

[HTML][HTML] Autonomic imbalance and atrial ectopic activity—A pathophysiological and clinical view

A Scridon - Frontiers in Physiology, 2022 - frontiersin.org
atrial ectopy, is widely recognized. The aim of this review is to discuss the main mechanisms
involved in atrial ectopic activity. … In atrial fibrillation, ectopic foci, most commonly located at …

Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps

A Xintarakou, S Tzeis, S Psarras, D Asvestas… - EP …, 2020 - academic.oup.com
… human atria the degree of fibrosis has been correlated with … are increased in cardiomyocytes
of patients with AF. In addition… cause ectopic firing and to enhance fibrosis formation in atrial

Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?

A Krishnan, E Chilton, J Raman, P Saxena… - Cells, 2021 - mdpi.com
Atrial fibrillation is characterized by chaotic, ectopic electrical activity and uncoordinated …
[6] are all correlated with increased risk of persistent atrial fibrillation. The most important …

Linking cellular energy state to atrial fibrillation pathogenesis: potential role of adenosine monophosphate–activated protein kinase

P Chakraborty, S Nattel, K Nanthakumar - Heart rhythm, 2020 - Elsevier
… The onset of AF was preceded by atrial conduction slowing and frequent atrial ectopic beats.
Although reversal of some pathological changes by genetic activation of AMPK has been …

Degree of fibrosis in human atrial tissue is not the hallmark driving AF

K S. Ramos, L Pool, MS van Schie, LFJM Wijdeveld… - Cells, 2022 - mdpi.com
atrial fibrillation (AF). In this current study, we investigated the relation between the degree
of fibrosis in human atrial tissue samples of controls and patients in … did not correlate with the …

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

D Bode, JRD Pronto, GG Schiattarella… - Nature Reviews …, 2024 - nature.com
… ablation are usually higher than in patients with paroxysmal AF 53 . On a cellular level,
ectopic activity is caused by abnormal automaticity or afterdepolarizations 54 (Fig. 1). Normal …

Electro-mechanical alterations in atrial fibrillation: Structural, electrical, and functional correlates

I Pozios, AI Vouliotis, P Dilaveris, C Tsioufis - Journal of Cardiovascular …, 2023 - mdpi.com
Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting
both patients’ … remodeling of the atrial myocardium leading to atrial fibrillation development. …

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

M Gawałko, A Saljic, N Li, I Abu-Taha… - Cardiovascular …, 2023 - academic.oup.com
… cardiac fat correlates with dilatation of the left atrium (LA), a … The ectopic (triggered) activity
is often the result of Ca 2+ -… cell-to-cell coupling and voltage-gated Na + channels governing …