Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
… Atrial fibrous-tissue content is increased in patients with pAF and atrial scarring correlates
with … At the same time, spontaneous atrial ectopic activity seems to be an important trigger for …
with … At the same time, spontaneous atrial ectopic activity seems to be an important trigger for …
Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review
KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
… is critical in triggering DADs and thus increased atrial ectopic activity. In human AF models,
… fibroblasts and epicardial adipose tissue (EAT) are positively correlated with atrial fibrosis …
… fibroblasts and epicardial adipose tissue (EAT) are positively correlated with atrial fibrosis …
[HTML][HTML] Autonomic imbalance and atrial ectopic activity—A pathophysiological and clinical view
A Scridon - Frontiers in Physiology, 2022 - frontiersin.org
… atrial ectopy, is widely recognized. The aim of this review is to discuss the main mechanisms
involved in atrial ectopic activity. … In atrial fibrillation, ectopic foci, most commonly located at …
involved in atrial ectopic activity. … In atrial fibrillation, ectopic foci, most commonly located at …
Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps
… human atria the degree of fibrosis has been correlated with … are increased in cardiomyocytes
of patients with AF. In addition… cause ectopic firing and to enhance fibrosis formation in atrial …
of patients with AF. In addition… cause ectopic firing and to enhance fibrosis formation in atrial …
Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?
A Krishnan, E Chilton, J Raman, P Saxena… - Cells, 2021 - mdpi.com
… Atrial fibrillation is characterized by chaotic, ectopic electrical activity and uncoordinated …
[6] are all correlated with increased risk of persistent atrial fibrillation. The most important …
[6] are all correlated with increased risk of persistent atrial fibrillation. The most important …
Linking cellular energy state to atrial fibrillation pathogenesis: potential role of adenosine monophosphate–activated protein kinase
P Chakraborty, S Nattel, K Nanthakumar - Heart rhythm, 2020 - Elsevier
… The onset of AF was preceded by atrial conduction slowing and frequent atrial ectopic beats.
Although reversal of some pathological changes by genetic activation of AMPK has been …
Although reversal of some pathological changes by genetic activation of AMPK has been …
Degree of fibrosis in human atrial tissue is not the hallmark driving AF
K S. Ramos, L Pool, MS van Schie, LFJM Wijdeveld… - Cells, 2022 - mdpi.com
… atrial fibrillation (AF). In this current study, we investigated the relation between the degree
of fibrosis in human atrial tissue samples of controls and patients in … did not correlate with the …
of fibrosis in human atrial tissue samples of controls and patients in … did not correlate with the …
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications
… ablation are usually higher than in patients with paroxysmal AF 53 . On a cellular level,
ectopic activity is caused by abnormal automaticity or afterdepolarizations 54 (Fig. 1). Normal …
ectopic activity is caused by abnormal automaticity or afterdepolarizations 54 (Fig. 1). Normal …
Electro-mechanical alterations in atrial fibrillation: Structural, electrical, and functional correlates
I Pozios, AI Vouliotis, P Dilaveris, C Tsioufis - Journal of Cardiovascular …, 2023 - mdpi.com
… Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting
both patients’ … remodeling of the atrial myocardium leading to atrial fibrillation development. …
both patients’ … remodeling of the atrial myocardium leading to atrial fibrillation development. …
Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance
… cardiac fat correlates with dilatation of the left atrium (LA), a … The ectopic (triggered) activity
is often the result of Ca 2+ -… cell-to-cell coupling and voltage-gated Na + channels governing …
is often the result of Ca 2+ -… cell-to-cell coupling and voltage-gated Na + channels governing …