Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care

J Heijman, H Sutanto, HJGM Crijns… - Cardiovascular …, 2021 - academic.oup.com
… levels, afterdepolarizations can induce focal ectopic firing, often arising from myocardial
sleeves around the pulmonary veins. Re-entrant activity initiated by ectopic activity acting on a …

Critical appraisal of technologies to assess electrical activity during atrial fibrillation: A position paper from the European heart rhythm association and European …

NMS De Groot, D Shah, PM Boyle, E Anter… - EP …, 2022 - academic.oup.com
correlate to sites of highest DF and highest regularity index (RI) ie sites of fastest and most
organized activity, and (… However, others argued that there is only a modest spatial correlation

[HTML][HTML] Decoding the PITX2-controlled genetic network in atrial fibrillation

JD Steimle, FJG Canozo, M Park, ZA Kadow… - Jci Insight, 2022 - ncbi.nlm.nih.gov
… To do this, we contrasted the correlation matrices of motifs at all accessible chromatin sites
… these ectopic beats, various cell types have been identified in the PVs of human patients and …

The effects of fibrotic cell type and its density on atrial fibrillation dynamics: An in silico study

LC Palacio, JP Ugarte, J Saiz, C Tobón - Cells, 2021 - mdpi.com
… The mechanisms of initiation and maintenance of AF include ectopic foci [4], multiple re-… in
patients with persistent AF [23,35,74] and the presence of these cells has been correlated with …

Emerging antiarrhythmic drugs for atrial fibrillation

A Saljic, J Heijman, D Dobrev - International Journal of Molecular …, 2022 - mdpi.com
… However, the molecular mechanisms promoting ectopic activity in the PVs of humans
remain largely unknown due to the very limited access to tissue samples. Animal models may …

Biomarkers of atrial fibrillation in hypertension

C Tsioufis, D Konstantinidis… - Current medicinal …, 2019 - ingentaconnect.com
… The correlation between AF (ΗΤΝ) and hypertension is already known. ΗΤΝ multiplies
the risk of new onset atrial fibrillation by 1.42 [7]. About 1 billion people all over the world are …

[HTML][HTML] Arriving on time: decoding macrophage involvement in atrial fibrillation

Y Yuan, N Li - The journal of cardiovascular aging, 2023 - ncbi.nlm.nih.gov
… alterations within atria. The pathophysiology of AF typically integrates ectopic activity and …
pronounced monocyte infiltration in their left atria, which correlates with atrial enlargement [5] . …

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring

SJRJ Logantha, SR Kharche, Y Zhang, AJ Atkinson… - Scientific Reports, 2019 - nature.com
… of ectopic foci, responsible for focal atrial tachycardia that can give rise to atrial fibrillation
Action potential amplitude significantly correlated with MDP in SN-C (r 2 = 0.79, P < 0.0001), …

The blinding period following ablation therapy for atrial fibrillation: proarrhythmic and antiarrhythmic pathophysiological mechanisms

LA Gottlieb, LRC Dekker, R Coronel - Clinical Electrophysiology, 2021 - jacc.org
Atrial fibrillation (AF) causes heart failure, ischemic strokes, and poor quality of life. The
number of patients with AF is estimated to increase to 18 million in Europe in 2050. …

Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling

KE Odening, S Deiß, D Dilling-Boer, M Didenko… - EP …, 2019 - academic.oup.com
… were greater in male cardiomyocytes than in females, which may contribute to increased
ectopic activity. … Epicardial fat correlates with a higher prevalence of AF, a progression to …