Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney … It
is considered as the underlying pathological process of chronic kidney disease (CKD), which …

Oxidative stress and renal fibrosis: mechanisms and therapies

H Su, C Wan, A Song, Y Qiu, W Xiong… - … Fibrosis: Mechanisms and …, 2019 - Springer
renal fibrosis as we elucidated above, and thus, targeting OS seems to be a promising strategy
in renal fibrosis … CKD progression by reducing renal fibrosis in preclinical or clinical trials. …

Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
… Furthermore, a better understanding of renal fibrosis is also favored to discover biomarkers
of fibrotic injury. In the review, we update recent advances in the mechanism of renal fibrosis

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
… demonstrating their importance for kidney disease (Buhl … renal fibrosis. While PDGF-C
deficiency or antagonism failed to protect from liver fibrosis, the lack of PDGF-C prevented kidney

Mesangial cells and renal fibrosis

JH Zhao - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
… in renal fibrosis. In this section, we will discuss how mesangial cells are activated and its
contributions to renal fibrosis, as well as the molecular mechanisms and novel anti-fibrotic

A glimpse of the mechanisms related to renal fibrosis in diabetic nephropathy

LF Zeng, Y Xiao, L Sun - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
… , the detailed molecular mechanisms still need … molecules will be defined in the future, which
is beneficial for developing the novel therapeutic strategies for the treatment of renal fibrosis

Cellular and molecular mechanisms underlying liver fibrosis regression

A Caligiuri, A Gentilini, M Pastore, S Gitto, F Marra - Cells, 2021 - mdpi.com
… In this review, we will discuss the major cellular and molecular mechanisms underlying the
regression of fibrosis/cirrhosis and the potential therapeutic approaches aimed at reversing …

Inflammatory mediators and renal fibrosis

XM Meng - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
kidney remains controversial. Collectively, understanding … cell functions and mechanisms
during renal fibrosis is paramount to improving diagnosis and treatment of chronic kidney

New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis

L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
… of renal fibrosis. Moreover, the cellular and molecular mechanisms mediating fibrosis are still
not … of the complex mechanisms and related cellular mediators of kidney fibrosis is urgently …

Molecular mechanisms of the acute kidney injury to chronic kidney disease transition: an updated view

F Guzzi, L Cirillo, RM Roperto, P Romagnani… - … journal of molecular …, 2019 - mdpi.com
fibrosis in the transition from AKI to CKD and highlight that progressive renal fibrosis requires
… primary interstitial disease is itself the triggering factor for fibrosis [23,77]. Recently, in a …