… and is expressed in pivotal brain regions (eg, the cerebral cortex and … The AChR changes
the ion-permeability of the cellular … age, which leads to the long-term increase of α7nAChR …

… However, research focused on the cellular distribution of nAChRs eventually shed some …
unchanged in the frontal and parietal cortices 55 . At the same age, APPswe mice showed no …

… to age-matched controls, there is a loss of M1 muscarinic … Using a functional rat cortical brain
slice model, we find that … mAChR protein expression in post-mortem temporal cortical tissue …

… lobe structures such as the hippocampus and entorhinal cortex [58]. In addition, separate …
mice also demonstrated greater age-dependent memory impairment, expression of amyloid …

… cortex. Current therapeutic approaches focus on restoring … The term cholinergic refers to the
receptors that respond to … scans to examine how age and AD impact muscarinic type 2 [M2] …

… We used total cellular protein staining as a method for the … protein expression and age of
death values were sampled from populations that approximately follow a Gaussian distribution. …

… receptors such as Ach muscarinic receptors (mAchRs) or … reduction in the expression of α7
nAchR in an age-dependent … fluid such as the cortical nicotinic receptor expression [50]. This …

… the basal forebrain cholinergic innervation of cortical areas is … in the expression of certain
GABA A receptor subunits, but, in … comparison with brain samples from age-matched patients. …

… Moreover, the dementia of Alzheimer’s and Parkinson’s … In the cerebral cortex, cholinergic
fibers are distributed in an intricate … Differential expression of cholinergic receptors in various …

… cholinergic pathways in the cerebral cortex and in the basal forebrain. In parallel, the nicotinic
acetylcholine receptor … neurodegenerative disorder in the elderly, and is characterized by …