… The ability of the immune system to distinguish between self and non-self is fundamental
to maintaining self-tolerance and breakdown of self-tolerance results in the positive selection …

… Self-tolerance of T cells is maintained by a combination of thymic negative selection and
suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC …

… T cell … mechanisms are rapidly activated to counterbalance T cell activation, thus
preventing excessive signal propagation and promoting the induction of immunological self-tolerance. …

… of the expression of the B cell receptor (BCR) classes discussed later in this article. [ 10-12
] … Here, other not yet characterized mechanisms are required to ensure self-tolerance. In full …

… a chaperone to transport misfolded intracellular proteins to the cell surface. In this study, we
… self-antigens and abrogate self-tolerance, providing a novel mechanism for autoimmunity. …

… Notably, inflammasome receptor molecules regulate the properties of different immune
cell effectors as well as non-immune cell types that is independent of classical activation and …

… Erythrocytes were then removed by exposure to red blood cell lysis buffer. Single cell …
Immature DCs prompted greater phagocytic and uptake capacity, and self-tolerance is …

… T cell receptors … mechanisms involved in breaking tolerance to self-antigens in the setting
of atherosclerosis are unknown. However, potential candidate mechanisms include T reg cell …

… In this review, we describe some nanotechnology-based approaches for the maintenance
of self-tolerance using the apoptotic cell clearance process (efferocytosis) that may be able to …

… B7 in the thymus before T cell export to the periphery would break self tolerance. In favor of
… cell lymphoproliferation and pathology in subsequent adult life, implying lack of self tolerance …