[HTML][HTML] Basic biology of hypoxic responses mediated by the transcription factor HIFs and its implication for medicine
K Hirota - Biomedicines, 2020 - mdpi.com
… O 2 acts as the final acceptor of electrons during oxidative phosphorylation, a series of ATP
… of the T-cell receptor/CD3 antigen complex may also activate HIF-1 in T-cell lymphocytes [201…
… of the T-cell receptor/CD3 antigen complex may also activate HIF-1 in T-cell lymphocytes [201…
[HTML][HTML] Small and large intestine (I): malabsorption of nutrients
MA Montoro-Huguet, B Belloc, M Domínguez-Cajal - Nutrients, 2021 - mdpi.com
… , as well as its clinical consequences, including both gastrointestinal symptoms … cell receptor
(TCR) and, in most cases, an unusual immunophenotype combining both T-cell and NK-cell …
(TCR) and, in most cases, an unusual immunophenotype combining both T-cell and NK-cell …
[HTML][HTML] Orthotopic T-cell receptor replacement—an “enabler” for TCR-based therapies
… routine clinical care difficult. In principle, genetic engineering can be used to make T-cell
therapies … We recently demonstrated that orthotopic T-cell receptor (TCR) replacement (OTR) by …
therapies … We recently demonstrated that orthotopic T-cell receptor (TCR) replacement (OTR) by …
Ligand binding at the protein–lipid interface: strategic considerations for drug design
J Payandeh, M Volgraf - Nature Reviews Drug Discovery, 2021 - nature.com
… of cellular membranes, including G protein-coupled receptors, … concepts and drug design
considerations to aid discovery … of BPTU and the hydrogen bond acceptors on the protein 17 . …
considerations to aid discovery … of BPTU and the hydrogen bond acceptors on the protein 17 . …
[HTML][HTML] Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies
M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
… cell receptors, it undergoes endocytosis, viral maturation, replication, and release of more
virus within the cytoplasm of the host cell. … very important clinical considerations for optimizing …
virus within the cytoplasm of the host cell. … very important clinical considerations for optimizing …
[HTML][HTML] Antiinflammatory actions of klotho: Implications for therapy of diabetic nephropathy
M Typiak, A Piwkowska - International Journal of Molecular Sciences, 2021 - mdpi.com
… in aberrant insulin production and lower sensitivity of acceptor cells of this hormone. The …
type II TGFβ receptors, thus preventing TGF-β1 attachment to its cell-surface receptors. The …
type II TGFβ receptors, thus preventing TGF-β1 attachment to its cell-surface receptors. The …
The sugar code: letters and vocabulary, writers, editors and readers and biosignificance of functional glycan–lectin pairing
H Kaltner, J Abad-Rodríguez, AP Corfield… - Biochemical …, 2019 - portlandpress.com
… or 8-positions of acceptors give the respective oligosaccharide a … As a consequence, beyond
the sequence, the type of … for the cases of the dendritic cell inhibitory receptor (DCIR) with a …
the sequence, the type of … for the cases of the dendritic cell inhibitory receptor (DCIR) with a …
Cellular-resolution imaging of bystander payload tissue penetration from antibody-drug conjugates
… 5) also has major clinical implications, not only in cases of limited … Mass balance completion
was performed using the acceptor … that would mediate receptor-mediated cell death in Ag + …
was performed using the acceptor … that would mediate receptor-mediated cell death in Ag + …
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
… acceptor cells and capacity for on-target binding at both cell-… AKT, ERK and Toll-like receptors)
95,105 and a decrease in … molecule in a cell can have unforeseen consequences for its …
95,105 and a decrease in … molecule in a cell can have unforeseen consequences for its …
[HTML][HTML] Historical and current adenosine receptor agonists in preclinical and clinical development
KA Jacobson, DK Tosh, S Jain, ZG Gao - Frontiers in cellular …, 2019 - frontiersin.org
… , non-alcoholic steatohepatitis, angina, sickle cell disease, ischemic conditions and diabetes
have been under development. Multiple clinical trials with two A 3 AR agonists are ongoing. …
have been under development. Multiple clinical trials with two A 3 AR agonists are ongoing. …