Research progress on adenosine in central nervous system diseases

YJ Liu, J Chen, X Li, X Zhou, YM Hu… - CNS neuroscience & …, 2019 - Wiley Online Library
… The main introduction sites are 2, 6, and 5′ on the bases and glycosyl in the treatment of
… and adenosine. In 2001, Berk showed that the function of the adenosine A2a receptor was …

Role of Adenosine A2A Receptors in the Central Fatigue of Neurodegenerative Diseases

ACB Alves, VJO Bristot, MD Limana… - … and Adenosine …, 2019 - liebertpub.com
… Caffeine is also the main ergogenic resource … that central fatigue can be mediated by A 2A
R in the central nervous system and that caffeine may be a good therapeutic option for central

Adenosine receptors in modulation of central nervous system disorders

H Choudhury, DK Chellappan… - Current …, 2019 - ingentaconnect.com
… Furthermore, these findings provide a detailed outline of the underlying genetic pathological
… Selective antagonism of adenosine A2A receptors reduces transmitter outflow. Neurobiol …

Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders

MR Domenici, A Ferrante, A Martire, V Chiodi… - Pharmacological …, 2019 - Elsevier
… which are the main obstacles to the … D2 receptors, metabotropic glutamate type 5 receptors
(mGlu5R) but also with the cannabinoid CB1 receptor and with other adenosine receptors, …

International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of emerging …

Adenosine A2A Receptors as Biomarkers of Brain Diseases

A Moreira-de-Sá, VS Lourenço, PM Canas… - Frontiers in …, 2021 - frontiersin.org
… , is a main source of increased extracellular levels of adenosine, which … receptors (A 1 R)
and increasing metabolic supply through A 2A R (Agostinho et al., 2020). Adenosine receptors

[HTML][HTML] How do adenosine A2A receptors regulate motor function?

A Mori - Parkinsonism & related disorders, 2020 - Elsevier
Adenosine A 2A receptor antagonism is a new therapeutic … This review addresses how
adenosine A 2A receptors are … and physiological function of the receptor, along with its …

[HTML][HTML] Pharmacological interactions between adenosine A2A receptor antagonists and different neurotransmitter systems

A Pinna, M Serra, J Marongiu, M Morelli - Parkinsonism & Related …, 2020 - Elsevier
Introduction Adenosine is extensively distributed in the central nervous system, where it
acts … Others suggest that the main actions of A 2A receptors are mediated through a dual …

Allosteric Modulation of Adenosine A2A Receptors as a New Therapeutic Avenue

M Korkutata, L Agrawal, M Lazarus - International Journal of Molecular …, 2022 - mdpi.com
… The therapeutic potential of targeting adenosine A 2A receptors (A 2A Rs) is immense
due to their broad expression in the body and central nervous system. The role of A 2A Rs in …

Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers

S Ferré, F Ciruela - Journal of Caffeine and Adenosine Research, 2019 - liebertpub.com
… In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites … Nevertheless, it is quite well established that the main mechanism involved in the …