Generation of cationic nanoliposomes for the efficient delivery of in vitro transcribed messenger RNA
T Michel, A Link, MK Abraham, C Schlensak… - JoVE (Journal of …, 2019 - jove.com
… their complexation and transfection efficacies using synthetic … transfection rate with negatively
charged nucleic acids 38 . … system, two of the key problems of drug delivery can be solved…
charged nucleic acids 38 . … system, two of the key problems of drug delivery can be solved…
Auto-associative lipid-based systems for non-viral nucleic acid delivery
V Escriou, N Mignet, A Miller - Introduction to Systems Biology; …, 2019 - books.google.com
… expression ( transfection ) of therapeutic nucleic acids such as … of cationic liposomes: A thin
lipid film on the walls of a glass … a chemical set of solutions looking for biological problems. …
lipid film on the walls of a glass … a chemical set of solutions looking for biological problems. …
Overcoming the delivery barrier of oligonucleotide drugs and enhancing nucleoside drug efficiency: The use of nucleolipids
X Zhou, S Wang, Y Zhu, Y Pan… - Medicinal Research …, 2020 - Wiley Online Library
… the transfection abilities offered by the nucleic acids of nucleolipids are ignored; only a few
works discuss it. The formation of nucleolipid/nucleic acid … and transportation problems that …
works discuss it. The formation of nucleolipid/nucleic acid … and transportation problems that …
[HTML][HTML] Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems
H Elsana, TOB Olusanya, J Carr-Wilkinson, S Darby… - Scientific reports, 2019 - nature.com
… They can overcome major viral issues such as … Liposomes can entrap different molecules
such as nucleic acids and … The aim of this research is to improve cationic liposome transfection …
such as nucleic acids and … The aim of this research is to improve cationic liposome transfection …
Impact of net charge, targeting ligand amount and mRNA modification on the uptake, intracellular routing and the transfection efficiency of mRNA lipopolyplexes in …
C Delehedde, I Ciganek, N Rameix, N Laroui… - International Journal of …, 2023 - Elsevier
… cell specificity is one of the challenges that must be tackled to … LPR exhibits higher colloidal
stability and nucleic acid … Then, the lipid film was further sonicated at 37 kHz by using an …
stability and nucleic acid … Then, the lipid film was further sonicated at 37 kHz by using an …
[引用][C] Microfluidics for size controlled cationic liposome DNA complexes: going beyond the universal transfection curve
CJO Ferreira, BFB Da Silva, MECD Real, ODC Botelho
[HTML][HTML] Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters
A Peletta, E Prompetchara, K Tharakhet, P Kaewpang… - Pharmaceutics, 2022 - mdpi.com
… ], with one of the main challenges being vaccine accessibility and … of fragile molecules such
as nucleic acids [13]. Previously, a … to be of lower transfection capacity. No fluorescence was …
as nucleic acids [13]. Previously, a … to be of lower transfection capacity. No fluorescence was …
Layer-by-Layer technique as a versatile tool for gene delivery applications
… nucleic acid release and cell transfection via electroporation from LbL-assembled film modified
with nucleic acid … at the same time, as the main challenges for the development of ex vivo …
with nucleic acid … at the same time, as the main challenges for the development of ex vivo …
Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
H Wang, L Qin, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2022 - Elsevier
… Still, issues of low transfection efficiency and poor tissue targeting of non-viral vectors need
… charged nucleic acids via electrostatic interactions. However, the transfection efficiency of …
… charged nucleic acids via electrostatic interactions. However, the transfection efficiency of …
[HTML][HTML] Fabrication of active targeting lipid nanoparticles: Challenges and perspectives
… Some groups tried to use antibodies aqueous solutions to hydrate plain lipid films [38]. …
another popular technique for lipid nanoparticle formulation, especially nucleic acid-loaded …
another popular technique for lipid nanoparticle formulation, especially nucleic acid-loaded …