The FDA “black box” warning on antidepressant suicide risk in young adults: more harm than benefits?

M Fornaro, A Anastasia, A Valchera, A Carano… - Frontiers in …, 2019 - frontiersin.org
… the development of suicidal ideation and behavior. The … a change in the position of the
FDA over time, soliciting revision and updating of the black box label warning for antidepressant

Increases in suicide deaths among adolescents and young adults following US Food and Drug Administration antidepressant boxed warnings and declines in …

CY Lu, RB Penfold, J Wallace… - … and clinical practice, 2020 - Am Psychiatric Assoc
… youth suicide deaths increased after the FDA antidepressant … increase monitoring for suicidal
thoughts and behavior at the start … compare changes in suicides after the warnings among …

Effect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA

M Plöderl, MP Hengartner - Crisis, 2021 - econtent.hogrefe.com
… assumptions about putative changes in suicide rates. Aims: To explore if putative changes
in suicide rates in adolescents and young adults at the time of the FDA warnings is a …

Antidepressant prescribing and suicide/self-harm by young Australians: regulatory warnings, contradictory advice, and long-term trends

M Whitely, M Raven, J Jureidini - Frontiers in psychiatry, 2020 - frontiersin.org
… increases the risk of suicide and self-harm by young people. Causal … Changes in suicide
rates and exposure to antidepressants in … the FDA warning of “suicidal ideation” but implied that …

Duty to warn: antidepressant black box suicidality warning is empirically justified

GI Spielmans, T Spence-Sing, P Parry - Frontiers in psychiatry, 2020 - frontiersin.org
… potential antidepressant-induced suicidality (suicidal thoughts, … that changes in the overall
population-level antidepressantFDA found increased likelihood of suicidal ideation/behavior

Antidepressants and Black Box Warning: Duty to Inform or Unintended Consequence of Cautious Response

S Naveed, V Urrutia, M Zeshan, H Akal… - Psychiatric …, 2021 - journals.healio.com
… , the FDA directed manufacturers of all antidepressant medications… box warning for possible
worsening suicidal thoughts and … in the FDA safety warnings corresponds to both changes in …

Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases

D Dubrall, S Fekete, S Leitzen, LM Paschke… - BMC pharmacology and …, 2023 - Springer
… Food and Drug Administration (FDA) Adverse Event Reporting … suicide/suicidal behaviour
or overdose for patients younger … (eg warnings, higher media attention, changes in guidelines) …

Assessing provider and racial/ethnic variation in response to the FDA antidepressant box warning

BL Cook, Y Wang, R Sonik, S Busch… - Health services …, 2019 - Wiley Online Library
… increased risk of suicidal ideation in youth… warning and changes in antidepressant use, we
are concerned in this study with the influence of the warning on provider and patient behavior

Employment effects of healthcare policy: Evidence from the 2007 FDA black box warning on antidepressants

A Bütikofer, CJ Cronin, MM Skira - Journal of Health Economics, 2020 - Elsevier
… , the warning of suicidality risk in 2007 targeted young adults … Our focus on an
antidepressant-related regulatory change and … of suicidal ideation, and potentially an increase in …

Risk of suicidal behaviors and antidepressant exposure among children and adolescents: a meta-analysis of observational studies

K Li, G Zhou, Y Xiao, J Gu, Q Chen, S Xie… - Frontiers in psychiatry, 2022 - frontiersin.org
… 1), though the FDA issued a “black box” warning for selective … suicidal behavior or ideation
in the young population, and the … , contrary to the therapeutic changes observed in adult rats. …