Increased mortality with delayed and missed switch to second-line antiretroviral therapy in South Africa

HB Gorrod, M Schomaker, G Maartens… - JAIDS Journal of …, 2020 - journals.lww.com
… variables—namely, CD4 cell count, VL, and treatment frequency—that change over time and
… to be used to improve the recognition and response to ART virologic failure in South Africa. …

Increased mortality with delayed and missed switch to second-line antiretroviral therapy in South Africa

H Bell Gorrod, M Schomaker… - JAIDS: Journal of …, 2020 - eprints.whiterose.ac.uk
… confounding variables – namely, CD4 cell count, VL and treatment frequency – that change
… to improve the recognition and response to ART virologic failure in 309 South Africa. 310 …

A superiority of viral load over CD4 cell count when predicting mortality in HIV patients on therapy

C Shoko, D Chikobvu - BMC infectious diseases, 2019 - Springer
… on anti-retroviral therapy (ART) who fulfilled the entry criteria … the CD4 cell count is low to
reduce the chances of reaction to … change and CD4 cell count helps in monitoring the risk of …

Joint modelling of longitudinal and time-to-event data: an illustration using CD4 count and mortality in a cohort of patients initiated on antiretroviral therapy

NN Mchunu, HG Mwambi, T Reddy… - BMC infectious …, 2020 - Springer
… suppressed patients in South Africa, however, the CD4 count still … response variables
simultaneously. The results in this study indicated that CD4 count change due to ART and mortality

CD4+ T-cell count at antiretroviral therapy initiation in the “treat-all” era in rural south africa: an interrupted time series analysis

HM Yapa, HY Kim, K Petoumenos… - Clinical Infectious …, 2022 - academic.oup.com
… HIV [8]; and risk of mortality is highest during the first few … CD4 counts ≤200 cells/μL
ranged from 27%–32% prior to the UTT policy change to 22%–26% after the UTT policy change

CD4 count recovery and associated factors among individuals enrolled in the South African antiretroviral therapy programme: an analysis of national laboratory based …

T Kufa, Z Shubber, W MacLeod, S Takuva, S Carmona… - PloS one, 2019 - journals.plos.org
Antiretroviral therapy (ART) reduces mortality and morbidity … CD4 cells from lymphoid organs,
and then slows down as new … In addition, there are little or no changes to CD4 count levels …

… of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral …

S Desmonde, AM Neilan, B Musick… - African Journal of …, 2020 - journals.lww.com
… ≥25%) and absolute CD4 cell count for older children aged ≥… response pattern post‐ART
[ 14 , 15 ]. If a patient only had one … Southern African research reported in this publication was …

… of predicted 10 years cardiovascular mortality risk with duration of HIV infection and antiretroviral therapy among HIV-infected individuals in Durban, South Africa

OO Todowede, B Sartorius, N Magula… - Diabetology & metabolic …, 2019 - Springer
… infected patients, altering HIV pathogenesis from an acute to … autoimmune response, ART
and the high cardiovascular risk … ART adherence and high CD4 count reduce the risk [16, 17]. …

Decreased HIV-associated mortality rates during scale-up of antiretroviral therapy, 2011–2016

G Otieno, YO Whiteside, T Achia, D Kwaro… - Aids, 2019 - journals.lww.com
changes in HIV-associated mortality rates in Gem from 1 … Responses to structured
questionnaires and HIV test results … could link clinic-based data on CD4 + cell counts, viral load, …

The health impact of free access to antiretroviral therapy in South Africa

C Burger, R Burger, E Van Doorslaer - Social Science & Medicine, 2022 - Elsevier
… on evaluating the relative difference in the changes in mortality and self-assessed ill-health …
of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral