ACE2 and gut amino acid transport

SMR Camargo, RN Vuille-dit-Bille, CF Meier… - Clinical …, 2020 - portlandpress.com
… Single cell RNA sequencing data analysis of colonicamino acid transporter expression
in the small intestine of Ace2 knockout mice, we observed that these animals lack intestinal B

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

AK Najumudeen, F Ceteci, SK Fey, G Hamm… - Nature …, 2021 - nature.com
… Using mouse models, we demonstrate that the Kras-mutant cells specifically upregulate the
amino acid transporter … In agreement with Slc7a5 induction in APC KRAS mice, this analysis

[HTML][HTML] Amino acid homeostasis in mammalian cells with a focus on amino acid transport

S Bröer, G Gauthier-Coles - The Journal of nutrition, 2022 - Elsevier
… in the colon (10, 11). … amino acid transporters (Figure 2) are expressed on the apical
membrane for the absorption of neutral amino acids (B 0 AT1, broad neutral amino acid transporter 1…

Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behavior

Y Yu, B Zhang, P Ji, Z Zuo, Y Huang, N Wang… - Nature …, 2022 - nature.com
… from colon of 12-week-old mice (pg/mg protein). n = 11 and 10 … To explore the effect of B.
uniformis on the intestinal … , we performed RNA-seq analysis of small intestinal cells. For the …

Amino acids in intestinal physiology and health

M Beaumont, F Blachier - … in Nutrition and Health: Amino acids in systems …, 2020 - Springer
… ); while for the colonocytes, the amino acid supply is believed to be … controversial as some
amino acid transporters have been … Metabolism of essential amino acids in colonic epithelial …

Amino acid transporters in the regulation of insulin secretion and signalling

K Javed, SJ Fairweather - Biochemical Society Transactions, 2019 - portlandpress.com
… We hypothesise the small intestine amino acid transporter B 0 … Advances in the characterisation
of amino acid transporters … expressed at limited levels in the colon, kidney, pancreas and …

Butyric acid and leucine induce α-defensin secretion from small intestinal Paneth cells

A Takakuwa, K Nakamura, M Kikuchi, R Sugimoto… - Nutrients, 2019 - mdpi.com
… As such, further analysis of whether Paneth cells express … amino acid transporter-2: LAT-2)
using a neutral amino acid … the butyric acid concentration in the human colon is around 12 …

[HTML][HTML] Amino acid metabolism, transport and signalling in the liver revisited

CC Paulusma, WH Lamers, S Broer… - Biochemical …, 2022 - Elsevier
… of hepatic amino acid transport. In Table 1 the expression of … More detailed analysis of
mRNA sequencing data obtained … levels in liver tissue were normal in TAT1 knock-out mice on …

L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism

M Sato, N Harada-Shoji, T Toyohara, T Soga, M Itoh… - Scientific reports, 2021 - nature.com
… are amino acid levels uptake via LAT1 with control set to 1 (B)… We performed a metabolomic
analysis of LAT1-knockout and … We used cells stably expressing hLAT1 (S2-LAT1), a mouse

[HTML][HTML] Amino acid transporters: emerging roles in drug delivery for tumor-targeting therapy

L Zhang, C Sui, W Yang, Q Luo - Asian Journal of Pharmaceutical Sciences, 2020 - Elsevier
… Firstly, the expression characteristics of amino acid transporters in … Furthermore, the
overexpressed ATB 0,+ in colorectal cancer … ATB 0,+ (system B 0,+ ) showed a wide selectivity of …