… , inhibitors targeting both the efflux transporter AcrB and the membrane fusion protein AcrA in
the Escherichia coli AcrAB-TolC efflux pump … The pyranopyridine compound MBX2319 and …

… Several AcrAB-TolC efflux pump inhibitors (EPIs) have been … pyranopyridines of the MBX
series [[17], [18], [19], [20]]. We recently reported the discovery of a novel class of AcrB inhibitors…

… of the highly efficient pyranopyridine efflux pump inhibitors. Our … In Escherichia coli, the
trimeric efflux pump AcrB is complexed with … coli genome, only AcrAB-TolC reveals constitutive …

… Another EPI that has been the subject of drug discovery efforts targeting AcrAB-TolC is
the pyranopyridine MBX2319 (Figure 7). This compound is chemical derived and has potent …

… are present, for example, in the OM of Escherichia coli (E. coli) and other enterobacteria. (12,13) …
We next analyzed the ability of compounds to inhibit AcrAB-TolC-mediated efflux using …

… a novel chemical scaffold able to boost antibiotic activity in E. coli by inhibiting the AcrAB-TolC
efflux pump. In … Both the pyridopyrimidine and pyranopyridine inhibitors bind to a specific “…

… as those belonging to pyranopyridine, naphthamide and … Other examples of efflux pump
inhibitors from plant sources … to have efflux pump inhibitory activity against the Bmr efflux pump, …

… EPIs active against Escherichia coli or Pseudomonas aeruginosa. … Pyranopyridines were
first described in 2014 by the US company MicroBiotix as AcrAB-TolC efflux pump inhibitors in E…

… inhibit the Escherichia coli RND efflux pump AcrAB-TolC and boost the activity of several
antibiotics. Here we have evaluated and characterized … inhibition of the RND efflux pumps in A. …

… Staphylococcus aureus, AcrAB-TolC in Escherichia coli, and … and activity of AcrAB-TolC
efflux pump is associated with a … as well as interactions of pyranopyridine compounds in the …