… proteasome targeting is rationalized by the existence of 2 types of direct proteasome signals
… modifications, which are recognized by proteasome regulatory subunits. Historically, the first …

… of targeted protein degradation through direct substrate recruitment to the 26S proteasome.
The … expressed in all cells; however, proteasomal ligands remain scarce. We identify potent …

… The proteolytic core of the proteasome has three pairs of active … proteasomes and describe
their utilization in the studies of the biology of the active sites and their roles as drug targets …

… 20S a better target for these diseases. (34,35) Here, we discuss approaches that have been
implemented in increasing both 20S and 26S proteasome-mediated proteolysis, challenges …

… proteins” (IDPs), are targeted by the proteasome. This review will provide an overview of …
on susceptibility to proteasomal degradation. We will then examine the proteasome with …

… blocks of the proteasome system, ie proteasome activators or … proteasome complexes
constituting an entire proteasome … for the defined targeting of distinct proteasome super-complexes …

… Accordingly, both HSP70 and HSP90 mediate proteasomal degradation of substrate/client
proteins [132,133,134,135,136]. Indeed, the involvement of chaperones in protein …

… CFZ-A6-PMs displayed good proteasome activity inhibition and … for targeted delivery of
proteasome inhibitors to CD44 + MM. … for CD44-targeted delivery of potent proteasome inhibitors. …

… proteasome has recently emerged as a desirable drug target… parasite-specific proteasome
inhibitors using substrate profiling… Targeting the parasite’s 20S proteasome chymotrypsin-like (…

… catalytic core particle (20S CP) and the 19S proteasome … therapeutic target of the next
generation of proteasome … are reported to target proteins for proteasome-mediated degradation [43…