… used gene expression signatures of a specific cancer type or … replication stress (RepStress)-related
gene expression … in multiple cancer models as it induces significant synergy …

… , such drugs have demonstrated poor bioavailability, chemical … of genes involved in the
cellular stress response and cell cycle … In EWS cells, disruption of DNMT1 induced by MC3343 …

… in regulating DNA damage-induced G2 checkpoint through … p53 gene is frequently mutated
or silenced in human cancer (… Consequently, chemical inhibition or depletion of NAT10 or …

… of genetic information to daughter cells. Following genotoxic … induced by TLS polymerases
can contribute to tumorigenesis 36 and impact the response of cancer cells to DNA-damaging …

… sensitivity to chemical drugs (mainly DNA-damaging agents, … of cancer cells to
chemotherapeutic drugs that induce DNA … of gene expression in the DDA drug class than in other …

… aspect of the specificity of the cancer cells response to the … induction of this miRNA in
cells treated with DOX or cis-Pt could indicate a response of the cancer cells to the DNA-damaging …

… through the background of cancer-specific DNA repair failure. … groups, which strongly chemical
binds to the nucleophilic … the secondary cancer induction, the DNA-reactive agents have a …

… can sensitize cancer cells to DNA-damaging agents. The … EMS is an alkylating agent
inducing mainly gene mutation. … cells,” Journal of Biological Chemistry, vol. 281, no. 52, pp. …

… therapy and to sensitize tumor cells to DNA-damaging agents… quantified using the TGX stain
free chemistry by Gel Doc EZ Gel … We also corroborate that inhibition of RSR genes induces …

… to identify true DNA damaging agents, assessed intra- and … cellular stress responses following
treatment with chemicals … using the three gene stress response panel described above. …