Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins

AI Masyuk, TV Masyuk, CE Trussoni, NE Pirius… - Hepatology, 2022 - journals.lww.com
… Jiaxi Song and Hao Song contributed equally to this work. … alpha (RORα) has been reported
to contribute to the development and function of several types of lymphocytes. For instance, …

[HTML][HTML] Autophagy-mediated reduction of miR-345 contributes to hepatic cystogenesis in polycystic liver disease

T Masyuk, A Masyuk, C Trussoni, B Howard, J Ding… - JHEP Reports, 2021 - Elsevier
… growth of hepatic cysts. We found that hepatic cystogenesis is increased when the levels
of miR-345 in PLD cholangiocytes (PLDCs) are reduced by autophagy. Restoration of miR-345 …

Genetics, pathobiology and therapeutic opportunities of polycystic liver disease

P Olaizola, PM Rodrigues… - Nature Reviews …, 2022 - nature.com
… of a cholangiocyte showing the localization and function of 12 … Hepatic cystogenesis is a
heterogeneous process … (including proliferation, survival, autophagy, aberrant proteostasis, …

Polycystic liver diseases: Genetics, mechanisms, and therapies

T Masyuk, A Masyuk, N LaRusso - The Liver: Biology and …, 2020 - Wiley Online Library
… emphasize the important contribution of autophagy in hepatic cystogenesis and suggest …
Cholangiocyte autophagy contributes to hepatic cys togenesis in polycystic liver disease and …

Polycystic liver disease: advances in understanding and treatment

TV Masyuk, AI Masyuk… - … : Mechanisms of Disease, 2022 - annualreviews.org
… -SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and …

New insights into targeting hepatic cystogenesis in autosomal dominant polycystic liver and kidney disease

TRM Barten, LHP Bernts, JPH Drenth… - Expert Opinion on …, 2020 - Taylor & Francis
… Introduction: Polycystic liver disease (PLD) is a rare disease defined by the growth of …
autophagy in hepatic cystogenesis by analyzing PCK rats [Citation64]. Analysis of cholangiocytes

[PDF][PDF] Polycystic liver diseases: from molecular basis to development of effective treatments

E Markaide, JM Bañales, PM Rodrigues - Rev Esp Enferm Dig, 2023 - online.reed.es
… hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental …
Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and …

Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: new therapeutic targets

A Santos‐Laso, L Izquierdo‐Sanchez… - Liver …, 2020 - Wiley Online Library
… in cystic cholangiocytes with the chemical chaperone 4-PBA halts hepatic cystogenesis in
… are characterized by increased autophagy, 33 as overexpression of lysosomal proteolysis …

[HTML][HTML] Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models

PY Lee-Law, P Olaizola, FJ Caballero-Camino… - Journal of …, 2021 - Elsevier
… ; this resulted in transcriptional activation of ubiquitin, and induction of autophagy markers, …
of proteins in the hepatic cystogenesis of PLD. Cystic cholangiocytes are characterized by …

Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease

R Ji, J Chen, Y Xie, X Dou, B Qing, Z Liu, Y Lu… - Journal of …, 2023 - Elsevier
… (eg Ube2h 52 and Ube2j2 53 ) regulation of autophagy (eg Atg7 49 and Atg14 49 ) and cell
cystic cholangiocytes, and dysregulation in MAPK cascade, vesicle transport and autophagy