The role of chondroitin sulfate proteoglycans in nervous system development

CP Mencio, RK Hussein, P Yu… - … of Histochemistry & …, 2021 - journals.sagepub.com
… In particular, chondroitin sulfate proteoglycans (CSPGs) have … brain. This review focuses
on current knowledge of the role of CSPGs in each of the major stages of neural development

Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders

X Yang - Reviews in the Neurosciences, 2020 - degruyter.com
… -transcriptionally modified by chondroitin sulfate glycosaminoglycans. CSPGs … neuronal
plasticity, axonal growth, and pathfinding during development as well as axonal regeneration

[HTML][HTML] Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs

AJ Hayes, J Melrose - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… and its PGs in neural development and in tissue morphogenesis in … roles of chondroitin sulfate
(CS) and dermatan sulfate (DS)-… axon regeneration, syndecan, is required for growth cone …

[HTML][HTML] Proteoglycan sulphation in the function of the mature central nervous system

JW Fawcett, JCF Kwok - Frontiers in Integrative Neuroscience, 2022 - frontiersin.org
… as chondroitin sulphate proteoglycans (CSPGs) and heparan sulphate proteoglycans (… in
the blockage of axon regeneration in the CNS, and also in regeneration failure in PNS injuries …

The emerging role of the chondroitin sulfate proteoglycan family in neurodegenerative diseases

J Lin, M Duan, N Lin, W Zhao - Reviews in the Neurosciences, 2021 - degruyter.com
… linked to proteins to form proteoglycans. Chondroitin sulfate proteoglycans (CSPGs) consist
of … Since neurons in the brain and spinal cord usually do not regenerate, excessive damage …

Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans

JR Siebert, DJ Osterhout - Journal of Neuroscience Research, 2021 - Wiley Online Library
… are highly inhibitory to neuronal regeneration and remyelination by endogenous … neuronal
survival and stimulate regeneration. In this study, neurotrophins that promote axonal growth

Targeting chondroitin sulfate proteoglycans: an emerging therapeutic strategy to treat CNS injury

N Mukherjee, S Nandi, S Garg, S Ghosh… - ACS Chemical …, 2020 - ACS Publications
… The key focus of this Viewpoint is to address a few important regenerative approaches …
CSPGs and other proteoglycans is the key to neuronal development. Chondroitin sulfate (CSPG) …

Keratan sulfate (KS)‐proteoglycans and neuronal regulation in health and disease: the importance of KS‐glycodynamics and interactive capability with …

J Melrose - Journal of Neurochemistry, 2019 - Wiley Online Library
Brain phosphacan a chondroitin sulfate, KS, HNK-1 PG have roles in neural development
and … indicate varied roles for KS-PGs in development and regenerative neural processes. …

Comparative analysis of the expression of chondroitin sulfate subtypes and their inhibitory effect on axonal growth in the embryonic, adult, and injured rat brains

MH Kim, SR Park, BH Choi - Tissue Engineering and Regenerative …, 2021 - Springer
Chondroitin sulfate glycosaminoglycans (CS-GAGs) are the primary inhibitory GAGs for
neuronal growth after central nervous system (… axonal growth, which was isolated from the brain

[HTML][HTML] Chondroitin sulfate proteoglycans revisited: its mechanism of generation and action for spinal cord injury

R Yang, Y Zhang, J Kang, C Zhang, B Ning - Aging and Disease, 2024 - ncbi.nlm.nih.gov
… Reactive astrocytes (RAs) produce chondroitin sulfate proteoglycans (CSPGs) in large
quantities after spinal cord injury (SCI) and inhibit axon regeneration through the Rho-associated …