Amorphous solid dispersion of nisoldipine by solvent evaporation technique: Preparation, characterization, in vitro, in vivo evaluation, and scale up feasibility study

RB Chavan, A Lodagekar, B Yadav… - Drug delivery and …, 2020 - Springer
… Also, ASD preparation from lab scale formulation technique … ASDs of nisoldipine were
prepared using rotary evaporation (… for selection of appropriate polymer in development of ASDs

Solvent influence on manufacturability, phase behavior and morphology of amorphous solid dispersions prepared via bead coating

E Boel, F Giacomini, G Van den Mooter - European Journal of …, 2021 - Elsevier
… The importance of solvent selection for ASD manufacturing … auspicious alternative
solvent-based ASD preparation method … influence of the solvent on ASDs prepared with bead …

Solvent-casted films to assist polymer selection for amorphous solid dispersions during preclinical studies: In-vitro and In-vivo Exploration

LI Mosquera-Giraldo, M Donoso, K Stefanski… - Pharmaceutical …, 2021 - Springer
… In the past, we used HPMCAS-MG as the default polymer to prepare ASDs for discovery
studies. This decision was based on the fact that HPMCAS-MG appeared to provide stable …

[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
… Thus, the presented methodology allows for an in-silico selection of appropriate solvent
systems for solvent-based ASD preparation based on a limited amount of experimental data for …

Phase behavior of pharmaceutically relevant polymer/solvent mixtures

S Dohrn, C Luebbert, K Lehmkemper… - International Journal of …, 2020 - Elsevier
… However, the selection of inappropiate solvents can lead to … to be appropriate solvents for
preparing ASDs based on … found to be appropriate solvents for ASD preparation using PVP K90…

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
… techniques for preparing ASDs. As physical stability is a critical quality attribute for ASD, the
Selection strategies are proposed to identify suitable manufacturing methods, which may …

Thermodynamic modeling of solvent-impact on phase separation in amorphous solid dispersions during drying

S Dohrn, P Reimer, C Luebbert… - Molecular …, 2020 - ACS Publications
… /water system showed the predicted liquid–liquid phase separation during drying and is
thus regarded as an inappropriate solvent choice for HPMCAS-based ASD preparation by …

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
… of preparation and characterization of ASDs with an emphasis on understanding and predicting
stability. Rational selection of polymers, preparation … using methods based on solvent

Comparison of amorphous solid dispersions of spironolactone prepared by spray drying and electrospinning: The influence of the preparation method on the …

E Szabó, P Záhonyi, D Brecska, DL Galata… - Molecular …, 2020 - ACS Publications
ASDs. Consequently, it is worth focusing on the selection of the appropriate ASD preparation
… The main goal of this work was to compare two different solvent-based ASD preparation

Corroborating various material-sparing techniques with hot melt extrusion for the preparation of triclabendazole amorphous solid dispersions

S Palekar, HK Mamidi, Y Guo, R Vartak… - International Journal of …, 2023 - Elsevier
… Amorphous solid dispersions (ASD) are one of the most … Formulation of ASDs using solvent
free methods such as hot … used for selecting suitable polymeric carriers for formulating ASDs. …