[HTML][HTML] Chromatin profiling reveals TFAP4 as a critical transcriptional regulator of bovine satellite cell differentiation
P Lyu, H Jiang - BMC genomics, 2024 - Springer
… These transcription factors include the myogenic regulatory … binding sites or motifs in
regulatory DNA regions called enhancers … In this study, we performed a genome-wide profiling of …
regulatory DNA regions called enhancers … In this study, we performed a genome-wide profiling of …
[HTML][HTML] Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of muscle stem cells during isolation
T Ozturk, J Mignot, F Gattazzo, M Gervais… - Stem Cell Research & …, 2024 - Springer
… We performed a transcriptomic profiling of MuSC … MAPK was the main player. Overall,
our data demonstrated that during dissociation, P38 MAPK and JNK contribute to the up-regulation …
our data demonstrated that during dissociation, P38 MAPK and JNK contribute to the up-regulation …
[HTML][HTML] p38 MAPKs—roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
CM Brennan, CP Emerson Jr, J Owens, N Christoforou - JCI insight, 2021 - ncbi.nlm.nih.gov
… of p38 MAPKs, including their role in regulating myogenesis … integrate multiple external cues
to control cellular functions. … –derived muscle cells uncovered multiple p38α/β inhibitors as …
to control cellular functions. … –derived muscle cells uncovered multiple p38α/β inhibitors as …
[HTML][HTML] Genome-wide identification of enhancers and transcription factors regulating the myogenic differentiation of bovine satellite cells
P Lyu, RE Settlage, H Jiang - BMC genomics, 2021 - Springer
… A set of four transcription factors called myogenic regulatory … was to further understand the
regulation of gene expression … a better understanding of gene regulation during satellite cell …
regulation of gene expression … a better understanding of gene regulation during satellite cell …
Restriction of cellular plasticity of differentiated cells mediated by chromatin modifiers, transcription factors and protein kinases
DP Rahe, O Hobert - G3: Genes, Genomes, Genetics, 2019 - academic.oup.com
… Ectopic expression of master regulatory transcription factors … genetic screens designed to
uncover novel factors involved in cell … One extrachromosomal line was integrated by gamma …
uncover novel factors involved in cell … One extrachromosomal line was integrated by gamma …
Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration
A Zhu, N Liu, Y Shang, Y Zhen, Y An - Chinese Medical Journal, 2022 - mednexus.org
… , active p38α upregulates the JNK phosphatase MAPK … [71] Chromatin-wide and transcriptome
profiling integration shows that p38α binds to a large set of active promoters to globally …
profiling integration shows that p38α binds to a large set of active promoters to globally …
Per1/Per2–Igf2 axis–mediated circadian regulation of myogenic differentiation
N Katoku-Kikyo, E Paatela, DL Houtz, B Lee… - Journal of Cell …, 2021 - rupress.org
… A circadian transcriptome analysis of muscle uncovered clustered expression of genes
with a common metabolic function at specific circadian phases in the mouse under constant …
with a common metabolic function at specific circadian phases in the mouse under constant …
p38α regulates expression of DUX4 in a model of facioscapulohumeral muscular dystrophy
LA Rojas, E Valentine, A Accorsi, J Maglio… - … of Pharmacology and …, 2020 - ASPET
… and characterization of p38α as a novel regulator of DUX4 … , potent, and specific inhibitors
of p38α/β, we show a robust … siRNAs against p38α and γ, the most abundant p38 MAPKs in …
of p38α/β, we show a robust … siRNAs against p38α and γ, the most abundant p38 MAPKs in …
Mechanosensitive pathways controlling translation regulatory processes in skeletal muscle and implications for adaptation
TJ Kirby - Journal of applied physiology, 2019 - journals.physiology.org
… regulation of mTORC1 in response to mechanical stretch appears to be independent of ERK1/2
signaling (120). The role of MAPK in regulating … will require the integration of novel tissue …
signaling (120). The role of MAPK in regulating … will require the integration of novel tissue …
Clinically advanced p38 inhibitors suppress DUX4 expression in cellular and animal models of facioscapulohumeral muscular dystrophy
J Oliva, S Galasinski, A Richey, AE Campbell… - … of Pharmacology and …, 2019 - ASPET
… Here, we identify p38α and p38β MAPKs as having important roles … Efforts to further explore
the signaling pathways regulating … These studies uncover the exciting possibility of a disease-…
the signaling pathways regulating … These studies uncover the exciting possibility of a disease-…