Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness

WH Roughan, AI Campos, LM García-Marín… - Frontiers in …, 2021 - frontiersin.org
… In summary, we found patients with comorbid depression and chronic pain were less likely
to derive functional benefits from antidepressants (especially sertraline, escitalopram, and …

The molecular neurobiology of chronic pain–induced depression

M Humo, H Lu, I Yalcin - Cell and tissue research, 2019 - Springer
… molecular aspects of the comorbid relationship of chronic pain and depression. We thus …
comorbid relationship between chronic pain and mood disorders, especially major depressive

A neural circuit for comorbid depressive symptoms in chronic pain

W Zhou, Y Jin, Q Meng, X Zhu, T Bai, Y Tian… - Nature …, 2019 - nature.com
Comorbid depressive symptoms (CDS) in chronic pain are a … depression. Inhibition of the
5-HT DRN →SOM CeA pathway … depression-like behavior in a male mouse model of chronic

[PDF][PDF] Depression trends in patients with chronic pain: an analysis of the nationwide inpatient sample

V Orhurhu, M Olusunmade, Y Akinola, I Urits… - Pain …, 2019 - researchgate.net
… of comorbid depression in patients with chronic pain. We included all patients with the diagnosis
of depression and chronic pain … the rate of comorbid depression and chronic pain in the …

Involvement of the hippocampus in chronic pain and depression

T Mokhtari, Y Tu, L Hu - Brain Science Advances, 2019 - journals.sagepub.com
Chronic pain commonly coexists with major depressive disorder (MDD) [1]. Up to 80% of …
with chronic pain have comorbid depressive symptoms [5]. Moreover, patients with chronic pain

The prevalence of psychiatric and chronic pain comorbidities in fibromyalgia: an ACTTION systematic review

BA Kleykamp, MKC Ferguson, E McNicol… - Seminars in arthritis and …, 2021 - Elsevier
… , myofascial pain syndrome, and temporomandibular disorders). The results of the review
suggest that depression and chronic pain conditions involving head/jaw pain and IBS were …

Extended overview of the longitudinal pain-depression association: a comparison of six cohorts treated for specific chronic pain conditions

F Angst, T Benz, S Lehmann, S Wagner… - Journal of affective …, 2020 - Elsevier
… and depression across different chronic pain syndromes … clear that the burden of pain and
depression is more salient in … longitudinal changes in pain and depression with and without …

Comorbid depression in medical diseases

SM Gold, O Köhler-Forsberg, R Moss-Morris… - Nature Reviews …, 2020 - nature.com
Comorbid depression has pronounced clinical implications as there is an additive or … of
depression and chronic medical diseases on overall health 3 . Importantly, comorbid depression

The mesolimbic dopamine system in chronic pain and associated affective comorbidities

RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
… Changes in the epigenetic landscape may also play critical roles in the transition from acute
to chronic pain, the maintenance of pain, or the development of comorbid depression. For …

How to study anxiety and depression in rodent models of chronic pain?

M Kremer, LJ Becker, M Barrot… - European Journal of …, 2021 - Wiley Online Library
… of the comorbid relationship between chronic pain and anxiety and/or major depressive
disorder. Three major types of chronic pain strongly associated with anxiodepressive-like …