[HTML][HTML] Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease

H Saito, K Tanaka, T Iwasaki, A Oda, S Watanabe… - Scientific Reports, 2021 - nature.com
… mellitus, dyslipidemia, or chronic kidney disease, and were … administered a xanthine oxidase
inhibitor after adjustment for … including fatal or nonfatal myocardial infarction, angina pectoris…

Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice

Y Tanaka, T Nagoshi, A Yoshii, Y Oi… - Free Radical Biology …, 2021 - Elsevier
… ) at 7 days after Dox administration with or without xanthine oxidase (XO) inhibitors treatment
([… the energy metabolism might differ from those in chronic Dox-treated models (that actually …

Xanthine Oxidase Inhibitor, Febuxostat Ameliorates the High Salt Intake–Induced Cardiac Hypertrophy and Fibrosis in Dahl Salt-Sensitive Rats

A Namai-Takahashi, A Sakuyama… - American Journal of …, 2019 - academic.oup.com
… with hyperuricemia after cardiac surgery. Animal studies reported beneficial effects of Fx in
HF models including dogs with pace maker–induced tachycardia, rabbits with coronary artery …

Omeprazole induces vascular remodeling by mechanisms involving xanthine oxidoreductase and matrix metalloproteinase activation

RC Nogueira, LC Pinheiro, JM Sanches-Lopes… - Biochemical …, 2021 - Elsevier
… Our results suggest that the long-term use of omeprazole induces vascular dysfunction and
… These findings contrast with our results showing beneficial effects of XOR inhibition after

[HTML][HTML] Effects of febuxostat on atrial remodeling in a rabbit model of atrial fibrillation induced by rapid atrial pacing

YY Fan, F Xu, C Zhu, WK Cheng, J Li… - Journal of Geriatric …, 2019 - ncbi.nlm.nih.gov
… the mitochondrial electron transport chain, xanthine oxidase (XO), … beneficial in chronic
heart failure (CHF), myocardial ischemia… , PA, USA) were performed after four weeks of RAP to …

Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y1 and P2Y12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than …

Y Lei, B Zhang, D Liu, J Zhao, X Dai… - Journal of medicinal …, 2020 - ACS Publications
… ), including unstable angina and acute myocardial infarction (AMI), … after the oral administration
of 24w. The hydrolysis rate of compound 24w in rat plasma was greater than that in rabbit

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DZ Xu, N Murakoshi, K Tajiri, F Duo, Y Okabe… - Clinical …, 2021 - portlandpress.com
… In brief, sections after antigen retrieval were incubated with rabbit polyclonal anti-connexin …
) followed by treatment with AlexaFluora-488 goat anti-rabbit IgG (1:500; Thermo Fisher) as a …

[HTML][HTML] Xanthine oxidoreductase: A leading actor in cardiovascular disease drama

L Polito, M Bortolotti, MG Battelli, A Bolognesi - Redox Biology, 2021 - Elsevier
inhibition restores eNOS-dependent vasodilation in aorta rings from hypercholesterolemic
rabbits … XOR activity and chronic heart failure severity and clinical outcome after adjustment for …

Codeine exerts cardiorenal injury via upregulation of adenine deaminase/xanthine oxidase and caspase 3 signaling

RE Akhigbe, LO Ajayi, AF Ajayi - Life Sciences, 2021 - Elsevier
… Male New Zealand rabbits received per os distilled water or … to have the highest rate of abuse
after cannabis, with about 32.4 … in the management of pain, myocardial infarction, and end-…

[PDF][PDF] … PARAMETERS AND HISTOPATHOLOGICAL CHANGING AGAINST ISOPROTERENOL INDUCED ACUTE MYOCARDIAL INFARCTION IN MALE RABBITS

ZAH AL-Mousawi, MH Al-Saeed - Basrah Journal of Veterinary Research, 2019 - iasj.net
… that induces severe stress in the myocardium when injected … may have a protective effect
against post-PCI cardiovascular … to protect against myocardial cell apoptosis by inhibition of …