Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung

X Hu, JD Chandler, S Park, K Liu, J Fernandes… - Free radical biology and …, 2019 - Elsevier
… In addition, targeted metabolomic analysis showed that these mice had increased
accumulation of mitochondrial carnitine and citric acid cycle intermediates. The results of redox …

Entry of glucose-and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells

I Clerc, D Abba Moussa, Z Vahlas, S Tardito… - Nature …, 2019 - nature.com
The susceptibility of CD4 T cells to human immunodeficiency virus 1 (HIV-1) infection is
regulated by glucose and glutamine metabolism, but the relative contributions of these nutrients …

[HTML][HTML] Regulation and function of the mammalian tricarboxylic acid cycle

PK Arnold, LWS Finley - Journal of Biological Chemistry, 2023 - ASBMB
cycle behavior is dynamic, and products of the TCA cycle can be co-opted in cancer and other
pathologic states. In this review, we revisit the TCA cycle… sustained TCA cycle function and …

Citric acid from Aspergillus niger: a comprehensive overview

BC Behera - Critical Reviews in Microbiology, 2020 - Taylor & Francis
… In the metabolism of all aerobic organisms, it is an intermediate in the citric acid cycle. Citric
acid is … Anhydrous citric acid is highly soluble in water, freely soluble in ethanol and sparingly …

[HTML][HTML] Citric acid and itaconic acid accumulation: variations of the same story?

L Karaffa, CP Kubicek - Applied microbiology and biotechnology, 2019 - Springer
… By this way, no carbon dioxide is lost what enabled molar yields of citric acid > 66%, the …
cycle. They also demonstrated that no further metabolism of citric acid by the citric acid cycle

[HTML][HTML] Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era

Z Tong, X Zheng, Y Tong, YC Shi, J Sun - Microbial cell factories, 2019 - Springer
Citric acid (2-hydroxy-propane-1,2,3-tricarboxylic acid) is known as an intermediate of the
tricarboxylic acid cycle that is … Citric acid is also the most important bulk product in the organic …

A non-canonical tricarboxylic acid cycle underlies cellular identity

PK Arnold, BT Jackson, KI Paras, JS Brunner, ML Hart… - Nature, 2022 - nature.com
… Genes were ranked on the basis of correlation with mal+2/cit+2, and gene set enrichment
analysis 35 of the gene set KEGG citric acid (TCA) cycle-associated genes (…

Citric acid bioproduction: the technological innovation change

A Amato, A Becci, F Beolchini - Critical reviews in biotechnology, 2020 - Taylor & Francis
Citric acid is considered one of the most valuable weak organic acids on the market and
its production by biotechnological approaches is a very interesting topic. Despite the related …

[HTML][HTML] Citric acid-mediated abiotic stress tolerance in plants

M Tahjib-Ul-Arif, MI Zahan, MM Karim, S Imran… - International journal of …, 2021 - mdpi.com
… catalysis and intermediate in the citric acid cycle, can be utilized for … of organic acids such
as ascorbate and aspartic acid (Figure 4) [9,… In summary, CA and other CA-derived TCA cycle

Microbial citric acid: Production, properties, application, and future perspectives

BC Behera, R Mishra, S Mohapatra - Food Frontiers, 2021 - Wiley Online Library
citric acid. In the present review, special attention has been paid to address the advanced
literature of citric acid … techniques, different factors affecting citric acid production, and product …