… sites, which are distinct from those of the other serine β-lactamases. Their substrate profile
is … This review aims to describe the current class D β-lactamases including the functional …

… the carbapenemase activity of class D β-lactamases (11). Evaluation of the carbapenemase
activity of other class D … carbapenemase activity that equals that of some known CHDLs (12). …

… between class D and class A or class C β-lactamases is only … Carbapenem-hydrolyzing class
D β-lactamases (CHDLs) are … Similar to class A β-lactamases, class D β-lactamases retain …

… Class D enzymes are all termed oxacillinase (OXA); … is then how class A β-lactamases
with carbapenemase activity, … that they are distinguished from other class A β-lactamases by …

… the same overall fold with class A and class D β-lactamases, penicillin-binding proteins (…
principally by transmissible β-lactamases (eg, ESBLs and serine carbapenemases, such as …

… , the most genetically as well as biochemically diverse is the class D β-lactamases (DBL),
few of which can incapacitate the complete spectrum of β-lactamases. DBLs, like class A and C…

… [Citation49] and those carbapenemases with serine in their … numbering scheme for class
D β-lactamases was proposed … to carbapenemases. The wide functional diversity within this …

… β-lactamases, including extended-spectrum β-lactamases (ESBLs) and carbapenemases
belonging to different molecular classes: … between class D and class A or class C β-lactamases …

… and dissemination of new β-lactamases, particularly class B and D carbapenemases, led to
the … However, it displays weak potency against class D β-lactamases (eg, OXA-48), and it is …

… Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are … this enzyme’s carbapenemase
activity and its preference of … structural characterization in class D β-lactamases. Additionally…